How is amyloidosis treated?
Primary amyloidosis frequently occurs in elderly patients, and therapy requires chemotherapy and/or ASCT to effect survival by reducing or eliminating the plasma cell clone responsible.
Survival is based on the patient’s age and the extent of tissue involvement, with cardiac involvement suggesting a particularly poor prognosis. Prednisolone and melphalan have modest benefits on survival, and newer LC-focused strategies, including ASCT derived from studies in myeloma, are now recommended.
The management of AA amyloidosis requires treatment of the underlying secondary disorder; AH treatment depends on the specific genetic mutation, and liver transplantation may be curative in some cases.
