How is Alport syndrome inherited?
The most common form of Alport syndrome is X-linked Alport syndrome (XLAS), which comprises 80% of cases.
Autosomal-recessive Alport syndrome (ARAS) comprises 15% of cases, and autosomal-dominant Alport syndrome (ADAS) is rare, comprising only 5% of cases.
Of children with XLAS, 10% to 15% have no family history of hematuria or kidney disease and are felt to represent de novo mutations.
