How does myeloma cause acute kidney injury (AKI)?
• Cast nephropathy
• Hypercalcemia-induced volume depletion
• Monoclonal immunoglobulin deposition disease (MIDD)
• Amyloidosis
• Proximal tubulopathy/Fanconi syndrome
• Cryoglobulinemia
The use of kidney biopsy to distinguish between these potential etiologies and to guide therapy is frequently required.
