How do the angiontensin II type 2 receptors modulate pain

How do the angiontensin II type 2 receptors modulate pain, and what clinical evidence exists for pain modulation?

Angiotensin II is a potent vasopressor hormone important in controlling blood pressure and volume in the cardiovascular system. It binds and stimulates at least two types of receptors: AT1 and AT2. AT2 is a G-protein-coupled receptor that plays a role in CNS function. AT2 receptors are expressed on small diameter nerve fibers and dorsal root ganglion cells. Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II. However, studies on ACE inhibitors have failed to show an effect on pain. Therefore, AT2 receptor antagonists have been developed for pain relief. A phase II study in postherpetic neuralgia randomized 183 patients to placebo or an AT2 receptor antagonist (EMA-401). The study met the primary endpoint of reduction in pain intensity. Secondary outcomes of onset, 30%/50% responder rate, McGill and Patient Global Impression of change were also met. The drug was safe and well tolerated.


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top