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Experimental evidence which suggests an autoimmune pathogenesis of LEMS
What experimental evidence suggests an autoimmune pathogenesis of LEMS?
Passive transfer of IgG from patients with LEMS to animals produces electrophysiologic defects characteristic of LEMS.
The LEMS IgG contains autoantibodies against voltage-gated calcium channels.
Sources
Graves M, Katz JS: Myasthenia gravis. Curr Treat Options Neurol 6:163-171, 2004.
