EUS guided CPB and CPN

What are the indications for EUS guided celiac plexus block (CPB) and CPN? What is the difference? Why do they work? 

  • The celiac plexus transmits pain sensations from the pancreas and most of the abdominal organs.
  • As a result, blockage of this transmission has been found to be effective in the therapy of pain. 
  • CPB refers to the use of steroid or local anesthetics to temporarily inhibit celiac plexus function in patients with uncontrolled pain secondary to chronic pancreatitis. 
  • CPN refers to the use of alcohol or phenol to produce neurolysis in patients with uncontrolled pain secondary to pancreatic cancer.
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