Enteric pathogens associated with reactive arthritis

What enteric pathogens are associated with reactive arthritis? 

  • Several enteric bacterial pathogens may be associated with postinfectious autoimmune arthritis syndromes. 
  • Salmonella, Yersinia, Campylobacter, and Shigella are most commonly associated. More recently, E. coli and C. difficile infection have been associated with arthralgia or arthritis syndromes as well.
  • In addition to asymmetric oligoarthritis, some patients may develop conjunctivitis or skin eruptions (keratoderma blennorrhagica or erythema nodosum).
  • Management includes the treatment of the inciting infection and then judicious use of antiinflammatory therapies (nonsteroidal antiinflammatory drugs, disease-modifying antirheumatic drugs, steroids).
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