Does Bone metabolism alter in high prolactin levels

Does Bone metabolism alter in high prolactin levels

Bone metabolism is altered when prolactin values are elevated. What is the mechanism for this effect? Is it reversible?

The resulting decrease in circulating estrogen or testosterone levels causes a corresponding decrease in osteoblastic bone formation and an increase in osteoclastic bone resorption. Consequently, there is a decrease in bone mineral density and progression to osteoporosis. Studies have suggested that normalization of prolactin levels restores bone density in most but not all patients, particularly those affected at an early age, before reaching peak bone mass in the third decade of life.


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