Differential diagnosis of Thromboangiitis Obliterans
What conditions should be included in the differential diagnosis of TO?
• Collagen vascular diseases (SLE, systemic sclerosis, mixed connective tissue disease).
• Vasculitis (PAN, GCA, Takayasu’s, cocaine, other small vessel vasculitides).
• Antiphospholipid antibody syndrome.
• Various blood dyscrasias (hyperviscosity syndrome, polycythemic vera, essential thrombocytosis).
• Occupational hazards (e.g., vibratory tools, hypothenar hammer syndrome).
• Embolic disease (thoracic outlet syndrome, myxoma, cholesterol embol).
• Ergot and amphetamine toxicity.
• Premature atherosclerosis.
• Other: pernio, frost bite.
