Differences between Blau syndrome and early onset sarcoidosis

Differences between Blau syndrome and early onset sarcoidosis?

  • • Nothing. They are the same disease and are also known as familial granulomatous arthritis.
  • • Characterized by recurrent granulomatous inflammation of the joints (polyarthritis or tenosynovitis), eyes (anterior uveitis or panuveitis), and skin (dermal granulomas) with onset before the age of 5 years.
  • • Other manifestations include multiple interphalangeal contractures, cranial neuropathies, fever, and large-vessel vasculitis.
  • • Associated with mutations in the NOD2/CARD15 gene on chromosome 16. Interestingly, different polymorphisms in NOD2/CARD15 are associated with susceptibility to Crohn’s disease; however, there is no bowel inflammation in Blau syndrome.
  • • Infliximab, corticosteroids, and anakinra have proven beneficial. Joint deformity and visual impairment can occur in nonresponders.
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top