Demographic Features of Sepsis associated acute kidney injury
What are the demographic characteristics of acute kidney injury resulting from sepsis?
Observational data have found Sepsis associated acute kidney injury occurs more commonly among elderly patients and females when compared with non-septic acute kidney injury.
Patients with Sepsis associated acute kidney injury are also more likely to have a higher burden of preexisting comorbid disease when compared with patients with non-septic acute kidney injury.
In particular, patients with Sepsis associated acute kidney injury have a higher prevalence of congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease (CKD), liver disease, diabetes mellitus, active malignancy, and immune system compromise.
Positive blood cultures are associated with a significantly higher risk of developing acute kidney injury (37% vs. 29%) and delays in administering antibiotics further increase the risk of developing acute kidney injury.
Patients with Sepsis associated acute kidney injury have been shown across a range of observational studies to have higher rates of oliguria, despite having received more fluid therapy and/or diuretic therapy when compared with patients with non-septic acute kidney injury or those with sepsis only.
Consequently, these patients are more likely to accumulate fluid and develop a positive fluid balance early in their clinical course.
Data have accumulated to suggest significant fluid accumulation is associated with worse clinical outcome in patients who are critically ill with acute kidney injury and should be avoided.
