Current belief about the causes and risk factors for IBS

What is the current belief about the causes and risk factors for IBS? 

The pathogenesis of IBS appears to be multifactorial. Factors believed to play a role in the pathogenesis of IBS include heritability and genetics, environment and social learning, diet, intestinal microbiota, low-grade inflammation, central processing of visceral sensations, gut dysmotility, and disturbances in the neuroendocrine system of the gut. 

IBS is the result of a complex interaction between psychosocial and physiologic factors via the brain-gut axis. Early life factors, such as family attitudes toward illness, major loss, or abuse history, or, possibly, genetic predisposition, may influence a person’s psychosocial development (e.g., psychological state, coping skills, social support, or susceptibility to life stress) or gut dysfunction (e.g., gut dysmotility or hypersensitivity). Although closely interrelated, the importance of any one factor in the generation of IBS symptoms varies greatly between individuals.

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