How does the wounds collagen composition compare between the early and late stages of wound healing?
- Type I collagen is the most abundant type of collagen in normal dermis (approximately 80% to 90%).
- During the early stages of wound healing, fibroblasts actively produce type III collagen, which may account for 30% of the collagen in a healing wound.
- By week 2, type I collagen again becomes the principal collagen produced by fibroblasts.
- During remodeling, type III collagen is replaced by type I collagen to restore the normal dermal collagen composition.
