clinical characteristics of eosinophilic synovitis

clinical characteristics of eosinophilic synovitis

  • • Many have a history of atopy; some have dermatographism.
  • • Both sexes, age of onset 20 to 50 years. Can occur in childhood.
  • • Minor trauma causes acute onset (within 12–24 hours) of painless monoarthritis (usually knee) without warmth or erythema. Trauma may activate mast cells which attract eosinophils.
  • • Synovial fluid shows mildly inflammatory fluid with up to 50% eosinophils. Charcot–Leyden crystals (bipyramidal, hexagonal-shaped crystal made of products of intracellular lipases in eosinophils) may be seen.
  • • Peripheral blood WBC count normal. Peripheral blood eosinophilia in only 10%. Most have a normal ESR.
  • • Attacks last 1 to 2 weeks. Can have recurrences. Therapy includes NSAIDs.
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