What chronic sequelae can be seen in patients with juvenile dermatomyositis?
• In severe chronic JDM, nodules resulting from subcutaneous calcinosis may be found (up to 40%). This is most common in patients with anti-NXP2 (MJ) antibodies. Mobility may be impaired because of calcinotic lesions at the joints or as a result of involvement of musculature. Infections can also occur where calcinosis breaks through the skin.
• Partial or generalized lipodystrophy can develop in 30% to 40% of patients with JDM. The face is frequently involved. It is frequently associated with the metabolic syndrome, insulin resistance, hirsuitism, clitoromegaly, and acanthosis nigricans. This is more common in patients with the anti-p155/140 (TIF-1λ) antibody.
