Can Fatty acids ingestion alter our inflammatory response to rheumatic disease

Can Fatty acids ingestion alter our inflammatory response to rheumatic disease?

Yes. FAs are essential to the human diet, with omega-3 and omega-6 FAs being the two major groups. FAs are responsible for the composition of the phospholipids in cellular membranes, and thus these membranes can be altered by dietary intake of omega-3 or omega-6 FA. Additionally, FAs are the precursors for LTs and PGs, the agents (among many) responsible for our inflammatory response. Omega-3 FAs are the precursors of PGE3 and LTB5, which are less inflammatory than PGE2 and LTB4 that come from omega-6 FA. Long-chain omega-3 FAs (Krill oil, fish [salmon] oil) are more effective than short-chain omega-3 FAs (plant oil, e.g., flaxseed). The recommended dose for dietary supplements containing long-chain omega-3 FA is 2000 mg/day (eicosapentaenoic acid [EPA] and docosahexaenoic acid combined) for a safe antiinflammatory effect.

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