Besides PR3 ANCA what other tests can be abnormal in Granulomatosis with polyangiitis?
The systemic inflammatory nature of GPA often results in anemia of chronic inflammation, leukocytosis, thrombocytosis, and elevation of the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Low serum albumin and elevated globulin levels may also be present. Importantly, leukopenia and thrombocytopenia are unusual , often helping to distinguish GPA from other autoimmune or neoplastic disorders.
Evidence of GN is suggested by the presence of hematuria, pyuria, cellular casts, and proteinuria. If renal function is compromised by the inflammatory process, elevated serum creatinine is expected. Other laboratory tests may be helpful in the investigation of specific end-organ damage, such as electrocardiography and echocardiography for pericarditis, nerve conduction velocity for mononeuritis multiplex, and magnetic resonance imaging for suspected OID.
