What parenteral anticoagulants are available to treat a patient with APS who has a history of HIT

What parenteral anticoagulants are available to treat a patient with APS who has a history of HIT?

• • Direct thrombin (IIa) inhibitor.
  • • Argatroban.
    • • Treatment of clot dose: 2 μg/kg/min IV.
    • • Monitor: PTT. Follow chromogenic factor X when transitioning to warfarin.
    • • Use cautiously with dose adjustment in liver insufficiency.
• • Synthetic pentasaccharide (inhibits factor Xa via antithrombin similar to heparin).
  • • Fondaparinux (Arixtra).
    • • Prophylactic dose: 2.5 mg SC q24 hours.
    • • Treatment of clot dose: 7.5 mg (if >50 kg weight) or 10 mg (if >100 kg weight) SC q24 hours.
    • • Monitor: antifactor Xa level 4 hours after dose.
    • • Do not use if CrCl <30 mL/minute.