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What is Vasopressin ADH
Vasopressin is a parenteral exogenous antidiuretic hormone (ADH) of the posterior pituitary gland indicated for diabetes insipidus, gastrointestinal radiography to dispel interfering gas shadows, prevention and treatment of postoperative abdominal distention, as well as to increase blood pressure in patients with vasodilatory shock who remain hypotensive despite fluids and catecholamines.
Endogenous ADH is a hormone secreted by the hypothalamus and stored in the posterior pituitary gland.
Commercial preparations of vasopressin exert the same pharmacologic effects as endogenous vasopressin.
Desmopressin (DDAVP) has a longer duration of action than vasopressin and a more favorable adverse effect profile and has replaced vasopressin as the drug of choice for central diabetes insipidus. DDAVP causes less stimulation of smooth muscle than vasopressin.
Brand Names
- Pitressin
- Vasostrict
Indications
- cardiac arrest
- cardiopulmonary resuscitation
- diabetes insipidus
- gastrointestinal radiography
- hypotension
- ileus
- post-cardiotomy shock
- pulseless electrical activity
- septic shock
- upper GI bleeding
- variceal bleeding
- ventricular asystole
Side Effects
- abdominal pain
- anaphylactic shock
- angina
- atrial fibrillation
- bleeding
- bradycardia
- cardiac arrest
- diabetes insipidus
- flatulence
- heart failure
- hyperbilirubinemia
- hyperhidrosis
- hyponatremia
- myocardial infarction
- nausea
- pallor
- peripheral vasoconstriction
- tremor
- urticaria
- vertigo
- vomiting
- water intoxication
Monitoring Parameters
- blood pressure
- heart rate
- serum electrolytes
- serum osmolality
- serum sodium
- weight
Contraindications
- asthma
- breast-feeding
- coronary artery disease
- heart failure
- migraine
- pregnancy
- renal disease
- seizure disorder
Interactions
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Articaine; Epinephrine
- Carbamazepine
- Chlorpropamide
- Citalopram
- Clomipramine
- Clozapine
- Corticorelin, Ovine
- Cyclophosphamide
- Demeclocycline
- Desipramine
- Desmopressin
- Dopamine
- Doxepin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Epinephrine
- Escitalopram
- Felbamate
- Fludrocortisone
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Foscarnet
- Furosemide
- Haloperidol
- Heparin
- Hydrochlorothiazide, HCTZ; Methyldopa
- Ifosfamide
- Imipramine
- Indomethacin
- Lithium
- Mecamylamine
- Methyldopa
- Norepinephrine
- Nortriptyline
- Paroxetine
- Pentamidine
- Perphenazine; Amitriptyline
- Prilocaine; Epinephrine
- Protriptyline
- Selective serotonin reuptake inhibitors
- Sertraline
- Tricyclic antidepressants
- Trimipramine
- Urea
- Vincristine
- Vincristine Liposomal
