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What is Ursodeoxycholic Acid and Ursodiol
Ursodeoxycholic acid, ursodiol is an oral, naturally occurring bile acid agent. Ursodiol is FDA-approved to solubilize radiolucent (cholesterol) gallstones, prevent gallstone formation in obese patients experiencing rapid weight loss, and for the treatment of patients with primary biliary cirrhosis.
Brand Name
- Actigall
- Urso 250
- Urso Forte
Indications
- biliary cirrhosis
- cholangitis
- cholelithiasis
- cholestasis
- gallstone prophylaxis
- intrahepatic cholestasis of pregnancy (ICP)
- non-alcoholic steatosis-hepatitis (NASH)
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- angioedema
- anorexia
- arthralgia
- asthenia
- chest pain (unspecified)
- constipation
- cough
- diabetes mellitus
- diarrhea
- dizziness
- dysmenorrhea
- dyspepsia
- elevated hepatic enzymes
- esophagitis
- fever
- flatulence
- headache
- hyperbilirubinemia
- hyperglycemia
- hypertension
- infection
- jaundice
- laryngeal edema
- leukopenia
- malaise
- musculoskeletal pain
- myalgia
- nausea
- peptic ulcer
- peripheral edema
- pharyngitis
- pruritus
- rash
- rhinitis
- thrombocytopenia
- urticaria
- vomiting
Monitoring Parameters
Monitoring Parameters
- cholecystogram
- gallbladder ultrasound
- LFTs
Contraindications
- ascites
- bile acid agents hypersensitivity
- biliary obstruction
- biliary tract disease
- biliary-GI fistula
- bleeding
- breast-feeding
- cholangitis
- encephalopathy
- esophageal varices
- geriatric
- jaundice
- pancreatitis
- pregnancy
Interactions
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Charcoal
- Cholestyramine
- Ciprofloxacin
- Colesevelam
- Colestipol
- Estrogens
- Fenofibrate
- Fenofibric Acid
- Fibric acid derivatives
- Gemfibrozil
