What's on this Page
What is Triptorelin
Triptorelin is a synthetic decapeptide agonist analog of gonadotropin-releasing hormone (GnRH) also known as luteinizing hormone releasing hormone (LHRH). Triptorelin is more potent than native GnRH.
Triptorelin has been widely used in Europe since 1986 as part of in vitro fertilization protocols and for treatment of hirsutism, endometriosis, or precocious puberty.
Triptorelin is FDA-approved in the United States for the palliative treatment of advanced prostate cancer and the treatment of central precocious puberty (CPP).
Psychiatric events have been reported in patients taking GnRH agonists; patients should be observed for a potential psychiatric event or worsening of psychiatric symptoms during triptorelin treatment.
Depression, including rare reports of suicidal ideation and attempt, has been reported with the use of GnRH agonists in children for CPP
Indications & Dosage
- breast cancer
- endometriosis
- hirsutism
- infertility
- precocious puberty
- prostate cancer
For the palliative treatment of advanced prostate cancer
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anxiety
- arthralgia
- asthenia
- back pain
- bone pain
- chest pain (unspecified)
- constipation
- cough
- depression
- diabetes mellitus
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- emotional lability
- fatigue
- gynecomastia
- headache
- hematuria
- hot flashes
- hyperglycemia
- hypertension
- impotence (erectile dysfunction)
- infection
- influenza
- injection site reaction
- insomnia
- libido decrease
- muscle paralysis
- myalgia
- myocardial infarction
- nausea
- ocular pain
- osteopenia
- osteoporosis
- peripheral edema
- peripheral neuropathy
- pharyngitis
- phlebitis
- pituitary apoplexy
- pneumonitis
- pruritus
- pulmonary embolism
- rash
- seizures
- sinusitis
- spinal cord compression
- stroke
- suicidal ideation
- testicular atrophy
- thrombosis
- tumor flare
- urinary retention
- urticaria
- vaginal bleeding
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- blood glucose
- bone age determination
- ECG
- glycosylated hemoglobin A1c (HbA1c)
- growth rate
- serum electrolytes
- serum gonadotropin concentrations
- serum testosterone
Contraindications
- alcoholism
- bradycardia
- brain tumor
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cerebrovascular disease
- coronary artery disease
- depression
- diabetes mellitus
- dysfunctional uterine bleeding
- females
- geriatric
- Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
- heart failure
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infertility
- long QT syndrome
- malnutrition
- menstruation
- myocardial infarction
- osteoporosis
- pituitary insufficiency
- pregnancy
- psychiatric event
- QT prolongation
- renal impairment
- seizure disorder
- spinal cord compression
- suicidal ideation
- thyroid disease
- urinary tract obstruction
- vaginal bleeding
Interactions
- Alfuzosin
- Amiodarone
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Androgens
- Apomorphine
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brexpiprazole
- Buprenorphine
- Buprenorphine; Naloxone
- Cariprazine
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Dasatinib
- Desflurane
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Ezogabine
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluvoxamine
- Foscarnet
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Inotuzumab Ozogamicin
- Isoflurane
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lefamulin
- Lenvatinib
- Levofloxacin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorcaserin
- Loxapine
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Methadone
- Methyldopa
- Metoclopramide
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Molindone
- Moxifloxacin
- Nilotinib
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pitolisant
- Posaconazole
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Romidepsin
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Tetrabenazine
- Thioridazine
- Thiothixene
- Tolterodine
- Toremifene
- Trandolapril; Verapamil
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verapamil
- Voriconazole
- Vorinostat
- Ziprasidone
