Prochlorperazine

Prochlorperazine Brand Names- Compazine | Compro

What is Prochlorperazine

Prochlorperazine, a piperazine phenothiazine, is an oral and parenteral antiemetic and antipsychotic agent.

It is most closely related to the high-potency neuroleptics such as perphenazine.

Prochlorperazine is mainly used for the management of nausea and vomiting but it shares many of the actions and adverse effects of the antipsychotics.

Prochlorperazine was approved by the FDA in 1956.

The branded product Compazine® was discontinued from production in 2003, but many generics are available.

On June 16, 2008, the FDA announced that it is requesting manufacturers of conventional antipsychotics to add a boxed warning to their product labeling regarding an increased risk of death in elderly patients with dementia receiving these drugs for behavioral problems.

This warning was first required in the product labeling of atypical antipsychotics in 2005, although recent data indicate an increased risk among both conventional and atypical antipsychotics

Indications

1. anxiety
2. migraine
3. nausea/vomiting
4. schizophrenia

For treatment of nausea/vomiting

Side Effects

1. agranulocytosis
2. akathisia
3. aplastic anemia
4. blurred vision
5. cholestasis
6. constipation
7. contact dermatitis
8. corneal opacification
9. dizziness
10. drowsiness
11. dystonic reaction
12. ejaculation dysfunction
13. eosinophilia
14. fever
15. galactorrhea
16. headache
17. hemolytic anemia
18. hyperprolactinemia
19. hypertension
20. hyperthermia
21. hyponatremia
22. hypotension
23. hypothermia
24. ileus
25. impotence (erectile dysfunction)
26. insomnia
27. jaundice
28. leukopenia
29. libido decrease
30. mastalgia
31. menstrual irregularity
32. mydriasis
33. nausea
34. neuroleptic malignant syndrome
35. neutropenia
36. orthostatic hypotension
37. pancytopenia
38. photosensitivity
39. polydipsia
40. priapism
41. pseudoparkinsonism
42. purpura
43. QT prolongation
44. retinopathy
45. seizures
46. SIADH
47. skin hyperpigmentation
48. tardive dyskinesia
49. thrombocytopenia
50. urinary retention
51. ventricular tachycardia
52. visual impairment
53. vomiting
54. water intoxication
55. weight gain
56. withdrawal
57. xerostomia

Monitoring Parameters

• CBC
• LFTs

Contraindications

• agranulocytosis
• alcoholism
• ambient temperature increase
• angina
• bradycardia
• breast cancer
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• children
• CNS depression
• coadministration with other CNS depressants
• coma
• coronary artery disease
• dehydration
• dementia
• diabetes mellitus
• driving or operating machinery
• ethanol ingestion
• females
• geriatric
• GI obstruction
• glaucoma
• heart failure
• hepatic disease
• hyperprolactinemia
• hypertension
• hyperthermia
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypotension
• hypothermia
• hypovolemia
• ileus
• infants
• infertility
• jaundice
• labor
• long QT syndrome
• malnutrition
• myocardial infarction
• neonates
• neurological disease
• neutropenia
• obstetric delivery
• orthostatic hypotension
• Parkinson’s disease
• phenothiazine hypersensitivity
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• QT prolongation
• radiographic contrast administration
• Reye’s syndrome
• seizure disorder
• strenuous exercise
• stroke
• surgery
• tardive dyskinesia
• thyroid disease
• urinary retention

Prochlorperazine is contraindicated for use in patients with known hypersensitivity to prochlorperazine or other phenothiazine hypersensitivity. Cross-sensitivity may occur with other phenothiazines.

Interactions

• Abarelix
• Acarbose
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetohexamide
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-glucosidase Inhibitors
• Alprazolam
• Amantadine
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Anticholinergics
• Anxiolytics; Sedatives; and Hypnotics
• Apomorphine
• Apraclonidine
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Azithromycin
• Baclofen
• Barbiturates
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benztropine
• Bepridil
• Beta-agonists
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Brexpiprazole
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Cabergoline
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carisoprodol
• Carteolol
• Cenobamate
• Central-acting adrenergic agents
• Ceritinib
• Cetrorelix
• Charcoal
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloral Hydrate
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroquine
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clemastine
• Clindamycin; Tretinoin
• Clobazam
• Clofazimine
• Clomipramine
• Clonazepam
• Clorazepate
• Clozapine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Crizotinib
• Cyclobenzaprine
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Dasatinib
• Deferoxamine
• Degarelix
• Desflurane
• Desipramine
• Desvenlafaxine
• Deutetrabenazine
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Diethylpropion
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Doxepin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Eliglustat
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Encorafenib
• Enflurane
• Entecavir
• Entrectinib
• Epinephrine
• Eprosartan; Hydrochlorothiazide, HCTZ
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Estazolam
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Ethosuximide
• Ethotoin
• Etomidate
• Ezogabine
• Felbamate
• Fenfluramine
• Fentanyl
• Fingolimod
• Flavoxate
• Flecainide
• Flibanserin
• Fluconazole
• Flucytosine
• Fluocinolone; Hydroquinone; Tretinoin
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluvoxamine
• food
• Foscarnet
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Gabapentin
• Ganirelix
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gilteritinib
• Glasdegib
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanidine
• Halobetasol; Tazarotene
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Histrelin
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ibutilide
• Iloperidone
• Imipramine
• Incretin Mimetics
• Indacaterol; Glycopyrrolate
• Indapamide
• Inotuzumab Ozogamicin
• Insulins
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Ipecac
• Irinotecan
• Irinotecan Liposomal
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Itraconazole
• Ivosidenib
• Ketamine
• Ketoconazole
• Lacosamide
• Lamotrigine
• Lanthanum Carbonate
• Lapatinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Leuprolide; Norethindrone
• Levetiracetam
• Levodopa
• Levofloxacin
• Levomethadyl
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Lithium
• Lofexidine
• Lomefloxacin
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorazepam
• Loxapine
• Lumateperone
• Lurasidone
• Macimorelin
• Magnesium Salts
• Maprotiline
• Meclizine
• Mefloquine
• Meglitinides
• Melatonin
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methoxsalen
• Methscopolamine
• Methsuximide
• Methyclothiazide
• Methylphenidate
• Metoclopramide
• Metolazone
• Metoprolol
• Metronidazole
• Metyrapone
• Metyrosine
• Midazolam
• Midostaurin
• Mifepristone
• Miglitol
• Minocycline
• Mirtazapine
• Mitotane
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Moxifloxacin
• Nabilone
• Nadolol
• Nafarelin
• Nalbuphine
• Naltrexone
• Nilotinib
• Nitroglycerin
• Non-Ionic Contrast Media
• Norepinephrine
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Orphenadrine
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxazepam
• Oxybutynin
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
• Paroxetine
• Pasireotide
• Pazopanib
• Pemoline
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perphenazine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Phenytoin
• Photosensitizing agents (topical)
• Pilocarpine
• Pimavanserin
• Pimozide
• Pindolol
• Pioglitazone
• Pitolisant
• Porfimer
• Posaconazole
• Pramipexole
• Pramlintide
• Pregabalin
• Prilocaine; Epinephrine
• Primaquine
• Primidone
• Procainamide
• Procarbazine
• Promethazine
• Propafenone
• Propantheline
• Propoxyphene
• Propranolol
• Protriptyline
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Rasagiline
• Remifentanil
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifamycins
• Rifapentine
• Rilpivirine
• Risperidone
• Romidepsin
• Ropinirole
• Rosiglitazone
• Rotigotine
• Safinamide
• Saquinavir
• Saxagliptin
• Scopolamine
• Secobarbital
• Segesterone Acetate; Ethinyl Estradiol
• Selpercatinib
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Simvastatin; Sitagliptin
• Siponimod
• Sitagliptin
• Sodium Oxybate
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Sorafenib
• Sotalol
• Sparfloxacin
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfonylureas
• Sunitinib
• Tacrolimus
• Tamoxifen
• Tapentadol
• Tazarotene
• Telavancin
• Telithromycin
• Temazepam
• Teniposide
• Tetrabenazine
• Thalidomide
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Tiagabine
• Timolol
• tobacco
• Tolazamide
• Tolbutamide
• Tolterodine
• Topiramate
• Toremifene
• Tramadol
• Trazodone
• Tretinoin, ATRA
• Triazolam
• Triclabendazole
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Trimipramine
• Triprolidine
• Triptorelin
• Trospium
• Valproic Acid, Divalproex Sodium
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Verteporfin
• Vigabatrin
• Voriconazole
• Vorinostat
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem
• Zonisamide