Prazosin Brand Name– Minipress
What is Prazosin
Prazosin is an oral agent used primarily to treat hypertension. It is classified as a quinazoline and is similar to the other alpha1-antagonists doxazosin and terazosin, both of which are longer acting than prazosin.
Prazosin has been used off-label to treat benign prostatic hypertrophy (BPH).
Prazosin also has been used in the treatment of heart failure; however, due to the development of tolerance, prazosin is seldom used for this condition today.
Prazosin was approved by the FDA in 1976.
Indications
- benign prostatic hyperplasia (BPH)
- hypertension
- hypertensive urgency
- posttraumatic stress disorder (PTSD)
- Raynaud’s phenomenon
For the treatment of hypertension
Side Effects
- abdominal pain
- alopecia
- angina
- anxiety
- arthralgia
- asthenia
- blurred vision
- bradycardia
- constipation
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspnea
- edema
- elevated hepatic enzymes
- epistaxis
- fatigue
- fever
- floppy iris syndrome
- flushing
- gynecomastia
- hallucinations
- headache
- hyperemia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- lichen planus-like eruption
- malaise
- nasal congestion
- nausea
- ocular pain
- orthostatic hypotension
- palpitations
- pancreatitis
- paresthesias
- peripheral edema
- priapism
- pruritus
- rash
- sinus tachycardia
- syncope
- tinnitus
- urinary incontinence
- urticaria
- vasculitis
- vertigo
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- blood pressure
Contraindications
- angina
- breast-feeding
- geriatric
- hypotension
- ocular surgery
- orthostatic hypotension
- pregnancy
- priapism
- syncope
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alprostadil
- Ambrisentan
- Amifostine
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amphetamines
- Amyl Nitrite
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apomorphine
- Apraclonidine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Avanafil
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Beta-blockers
- Bortezomib
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Calcium-channel blockers
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Central-acting adrenergic agents
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone; Clonidine
- Clevidipine
- Clonidine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Codeine; Phenylephrine; Promethazine
- Darolutamide
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Ephedrine
- Epinephrine
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etomidate
- Felodipine
- Fenoldopam
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- General anesthetics
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Indapamide
- Intravenous Lipid Emulsions
- Irbesartan
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isradipine
- Ketamine
- Levodopa
- Lisinopril
- Lofexidine
- Loop diuretics
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin; Niacin
- Lurasidone
- Mecamylamine
- Mestranol; Norethindrone
- Methohexital
- Methyldopa
- Methylphenidate
- Midodrine
- Milrinone
- Minoxidil
- Moexipril
- Naproxen; Pseudoephedrine
- Nebivolol; Valsartan
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicardipine
- Nicotine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Olmesartan
- Oxymetazoline
- Paliperidone
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Potassium-sparing diuretics
- Prilocaine; Epinephrine
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinapril
- Quinidine
- Ramipril
- Rasagiline
- Reserpine
- Risperidone
- Ritodrine
- Sacubitril; Valsartan
- Segesterone Acetate; Ethinyl Estradiol
- Sevoflurane
- Sildenafil
- Silodosin
- Tadalafil
- Tafamidis
- Tamsulosin
- Telmisartan
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiazide diuretics
- Thiopental
- Thiothixene
- Tizanidine
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Valsartan
- Vardenafil
- Verapamil
- Yohimbine
- Ziprasidone
