Polymyxin B and Trimethoprim Brand Name– Polytrim
What is Polymyxin B and Trimethoprim
Polymyxin B and trimethoprim are combined in an ophthalmic preparation for the treatment of acute bacterial ocular infections.
Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa. Trimethoprim is a synthetic antiinfective agent.
Polymyxin B has activity against gram-negative aerobic bacteria, including Pseudomonas aeruginosa, while trimethoprim is effective against both gram-positive and gram-negative organisms.
The FDA approved this combination eye product in October 1988.
Indications
- bacterial conjunctivitis
- blepharoconjunctivitis
- Escherichia coli
- Haemophilus aegyptius
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella pneumoniae
- Proteus mirabilis
- Proteus vulgaris
- Pseudomonas aeruginosa
- Serratia marcescens
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Viridans streptococci
Side Effects
- edema
- epiphora
- erythema
- ocular irritation
- ocular pruritus
- pruritus
- rash
- superinfection
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- contact lenses
- infants
- infection
- neonates
- polymyxin hypersensitivity
- pregnancy
- trimethoprim hypersensitivity
Interactions
There are no drug interactions associated with Polymyxin B and Trimethoprim products.
