Podophyllum Brand Name– Podocon-25
What is Podophyllum
Podophyllum is a topical cytotoxic agent. It is used to treat genital warts (condylomata acuminata).
According to the CDC, podophyllum is no longer recommended as a treatment of external genital warts because of safer alternative options.
Podophyllum arrests mitosis in the metaphase to cause the cytotoxic effects.
This drug was approved by the FDA in 1945.
Indications
- condylomata acuminata
- human papillomavirus (HPV) infection
For the removal of soft genital warts (condylomata acuminata) due to human papillomavirus (HPV) infection
Side Effects
- coma
- fever
- ileus
- leukopenia
- neuritis
- paresthesias
- thrombocytopenia
Monitoring Parameters
- CBC
Contraindications
- breast-feeding
- corticosteroid therapy
- diabetes mellitus
- ocular exposure
- peripheral vascular disease
- pregnancy
- skin disease
Interactions
- Imiquimod
- Podofilox
Imiquimod: (Minor) While no drug interactions have been reported with imiquimod, there is no clinical experience with imiquimod cream therapy immediately following the treatment of genital/perianal warts with other cutaneously applied drugs, such as podophyllum resin. Therefore, imiquimod cream administration is not recommended until skin is healed from any previous topical drug treatments or surgery.
Podofilox: (Minor) No drug interactions of clinical significance have been noted for podofilox. While no drug interactions have been reported, there is no clinical experience with podofilox immediately following the treatment of genital/perianal warts with other cutaneously applied drugs like podophyllum resin. Therefore, podofilox administration is not recommended until genital and/or perianal tissue is healed from any previous topical drug treatment or surgery
