Plazomicin Brand Name– ZEMDRI
What is Plazomicin
Plazomicin is a parenteral aminoglycoside antibiotic indicated for complicated urinary tract infections (cUTI), including pyelonephritis, caused by certain Enterobacteriaceae in adults.
Due to limited safety and efficacy data, reserve plazomicin use for patients who have limited or no alternative treatment options.
Plazomicin is not inhibited by most aminoglycoside-modifying enzymes known to affect gentamicin, amikacin, and tobramycin; therefore, plazomicin may be effective for certain gram-negative infections that are resistant to other aminoglycosides.
Therapeutic drug monitoring with plazomicin trough concentrations is recommended for patients with diminished renal function.
The major adverse reactions associated with plazomicin are due to drug-related nephrotoxicity, ototoxicity, and neuromuscular blockade
Indications
- Citrobacter freundii
- Citrobacter koseri
- Enterobacter cloacae
- Escherichia coli
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Morganella morganii
- Proteus mirabilis
- Proteus vulgaris
- Providencia stuartii
- pyelonephritis
- Serratia marcescens
- urinary tract infection (UTI)
Side Effects
- constipation
- diarrhea
- dizziness
- dyspnea
- elevated hepatic enzymes
- gastritis
- headache
- hearing loss
- hematuria
- hypertension
- hypokalemia
- hypotension
- nausea
- nephrotoxicity
- ototoxicity
- pseudomembranous colitis
- renal failure (unspecified)
- renal tubular acidosis (RTA)
- renal tubular necrosis
- tinnitus
- vertigo
- vomiting
- weakness
Monitoring Parameters
- serum aminoglycoside concentrations
- serum creatinine
Contraindications
- aminoglycoside hypersensitivity
- breast-feeding
- colitis
- diarrhea
- geriatric
- GI disease
- hearing impairment
- inflammatory bowel disease
- myasthenia gravis
- nephrotoxicity
- neuromuscular blockade
- neuromuscular disease
- ototoxicity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- ulcerative colitis
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Diphenhydramine
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Aminosalicylate sodium, Aminosalicylic acid
- Aprotinin
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atracurium
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bleomycin
- Bumetanide
- Capreomycin
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carboplatin
- Cefepime
- Cefotaxime
- Cefotetan
- Cefoxitin
- Cefprozil
- Ceftazidime
- Ceftazidime; Avibactam
- Ceftizoxime
- Cefuroxime
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisatracurium
- Cisplatin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Cyclizine
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Deferasirox
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxacurium
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Entecavir
- Ethacrynic Acid
- Fluphenazine
- Foscarnet
- Furosemide
- Gallium
- Gallium Ga 68 Dotatate
- Ganciclovir
- Ginger, Zingiber officinale
- Gold
- Hyaluronidase, Recombinant; Immune Globulin
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibandronate
- Ibuprofen lysine
- Immune Globulin IV, IVIG, IGIV
- Inotersen
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Isosulfan Blue
- Lamivudine; Tenofovir Disoproxil Fumarate
- Magnesium Salicylate
- Mannitol
- Meclizine
- Meperidine; Promethazine
- Mesoridazine
- Mivacurium
- Neuromuscular blockers
- Non-Ionic Contrast Media
- Oral Contraceptives
- Pamidronate
- Pancuronium
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Polymyxin B
- Polymyxins
- Promethazine
- Pyridostigmine
- Rapacuronium
- Rocuronium
- Salicylates
- Salsalate
- Scopolamine
- Streptozocin
- Succinylcholine
- Tacrolimus
- Telavancin
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Thioridazine
- Torsemide
- Trifluoperazine
- Trimethobenzamide
- Tubocurarine
- Urea
- Valacyclovir
- Valganciclovir
- Vancomycin
- Vecuronium
- Zalcitabine, ddC
- Zoledronic Acid
