Pirfenidone Brand Name– ESBRIET
What is Pirfenidone
Pirfenidone is an oral pyridone for the treatment of idiopathic pulmonary fibrosis. During randomized, double-blind, placebo-controlled trials, pirfenidone significantly reduced decline in forced vital capacity (FVC).
Differences in mean decline in FVC over time between treatment groups ranged from 157 to 193 mL.
All-cause mortality was not significantly affected by pirfenidone across clinical trials and available follow-up periods.
Liver enzyme elevations and drug-induced liver injury have been associated with pirfenidone; therefore, liver function monitoring is necessary during therapy.
Pirfenidone was FDA-approved in 2014
Indications
- pulmonary fibrosis
Side Effects
- abdominal pain
- agranulocytosis
- anorexia
- arthralgia
- asthenia
- chest pain (unspecified)
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- elevated hepatic enzymes
- fatigue
- gastroesophageal reflux
- headache
- hepatotoxicity
- hyperbilirubinemia
- infection
- insomnia
- jaundice
- nausea
- photosensitivity
- pruritus
- rash
- sinusitis
- vomiting
- weight loss
Monitoring Parameters
- LFTs
Contraindications
- breast-feeding
- cholestasis
- dialysis
- hepatic disease
- hepatitis
- hepatotoxicity
- jaundice
- pregnancy
- renal disease
- renal failure
- renal impairment
- sunlight (UV) exposure
- tobacco smoking
Interactions
- Amiodarone
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Carbamazepine
- Cimetidine
- Ciprofloxacin
- Citalopram
- Cobicistat
- Cobimetinib
- Dabigatran
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Disulfiram
- Dronabinol
- Edoxaban
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Fluvoxamine
- Fosamprenavir
- Ivabradine
- Lesinurad
- Lesinurad; Allopurinol
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Maraviroc
- Mexiletine
- Mirabegron
- Nebivolol
- Nebivolol; Valsartan
- Obeticholic Acid
- Ombitasvir; Paritaprevir; Ritonavir
- Osilodrostat
- Paroxetine
- Peginterferon Alfa-2b
- Porfimer
- Ritonavir
- Rolapitant
- Rucaparib
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Telotristat Ethyl
- Tenofovir Alafenamide
- Thiabendazole
- Vemurafenib
- Verteporfin
- Zafirlukast
- Zileuton
