Piperacillin and Tazobactam Brand Name– Zosyn
What is Piperacillin and Tazobactam
Piperacillin and tazobactam are combined in a single intravenous formulation to provide a broad spectrum of activity.
Piperacillin and tazobactam is commonly used to treat serious nosocomial infections that are often polymicrobial in nature.
Piperacillin, a ureidopenicillin, is an extended-spectrum penicillin. Tazobactam, an irreversible beta-lactamase inhibitor, prevents beta-lactamase destruction of piperacillin. Tazobactam blocks the activity of susceptible beta-lactamases, thus enhancing the intrinsic activity of piperacillin.
Piperacillin and tazobactam in a ratio of 8:1 is effective in the treatment of moderate to severe polymicrobial infections, including intra-abdominal, skin and soft-tissue, and lower respiratory tract infections.
The combination, however, does not have any more activity against Pseudomonas aeruginosa than does piperacillin alone.
Indications
- Acinetobacter baumannii
- appendicitis
- Bacillus anthracis
- bacteremia
- Bacteroides fragilis
- Bacteroides ovatus
- Bacteroides thetaiotaomicron
- Bacteroides vulgatus
- biliary tract infections
- cellulitis
- cholangitis
- cholecystitis
- Citrobacter koseri
- Clostridium perfringens
- community-acquired pneumonia
- cystic fibrosis
- diabetic foot ulcer
- endocarditis
- endometritis
- Enterobacter sp.
- Enterococcus faecalis
- Escherichia coli
- febrile neutropenia
- Fusobacterium nucleatum
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal abscess
- intraabdominal infections
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Moraxella catarrhalis
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- nosocomial pneumonia
- Parabacteroides distasonis
- pelvic inflammatory disease (PID)
- peritonitis
- pleural empyema
- pneumonia
- Prevotella melaninogenica
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- pyelonephritis
- Salmonella enteritidis
- sepsis
- Serratia marcescens
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- surgical infection prophylaxis
- urinary tract infection (UTI)
- Viridans streptococci
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- arthralgia
- bleeding
- bullous rash
- candidiasis
- constipation
- delirium
- diarrhea
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspepsia
- elevated hepatic enzymes
- eosinophilia
- eosinophilic pneumonia
- epistaxis
- erythema multiforme
- exfoliative dermatitis
- fever
- flushing
- headache
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hyperglycemia
- hypernatremia
- hypoglycemia
- hypokalemia
- hypotension
- injection site reaction
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- maculopapular rash
- myalgia
- nausea
- neutropenia
- pancytopenia
- phlebitis
- platelet dysfunction
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- purpura
- rash
- renal failure (unspecified)
- seizures
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- anticoagulant therapy
- bleeding
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- critical illness
- cystic fibrosis
- dialysis
- diarrhea
- geriatric
- hypokalemia
- laboratory test interference
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- seizure disorder
- sexually transmitted disease
- sodium restriction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atracurium
- Betrixaban
- Bivalirudin
- Choline Salicylate; Magnesium Salicylate
- Cisatracurium
- Colchicine; Probenecid
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Digoxin
- Edoxaban
- Enoxaparin
- Erythromycin; Sulfisoxazole
- Ethacrynic Acid
- Fondaparinux
- Furosemide
- Heparin
- Indomethacin
- Lepirudin
- Magnesium Salicylate
- Methotrexate
- Mivacurium
- Oral Contraceptives
- Pancuronium
- Pentosan
- Probenecid
- Pyrimethamine; Sulfadoxine
- Rivaroxaban
- Rocuronium
- Salsalate
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Tetracyclines
- Tinzaparin
- Typhoid Vaccine
- Vancomycin
- Vecuronium
- Warfarin
