What's on this Page
Phytonadione Vitamin K1 Brand Names- AquaMEPHYTON | Mephyton
What is Phytonadione Vitamin K1
Phytonadione is a synthetic compound that is chemically indistinguishable from naturally occurring vitamin K1 (phylloquinone). Vitamin K received its name in 1935 when it was called ‘Koagulationsvitamin’, which means ‘clotting vitamin.’
Vitamin K refers to a group of compounds that have a common methylated naphthoquinone ring and vary in the aliphatic side chain at the 3 position. Since the naphthoquinone ring is the functional group, all K vitamins have a similar mechanism of action.
However, there are substantial differences in absorption, bioavailability, transport, and tissue distribution due to the different lipophilicities of the side chains and the different foods in which K vitamins are found. Vitamin K is found in both plant and animal sources.
Phylloquinone, the most common form of vitamin K, is found in green vegetables (e.g., broccoli, brussel sprouts, collard greens, lettuce, and spinach) and plant oils (e.g., soybean and canola oils). Menaquinones (MK), or vitamin K2, are referred to in terms of the length of the aliphatic side chain (MK-4 to MK-10).
Menaquinones can be synthesized by bacteria and are also found in relevant quantities in meat, especially in liver (MK-4), and fermented products, cheese, and curd (MK-7 through MK-9).
In Japan, intake of MK-7 is high because it is found in large amounts in natto, a Japanese food made of fermented soybeans. The distal colon contains primarily MK-10, with lesser amounts of MK-7, MK-8, and MK-11, which are synthesized by bacteria.
These compounds are tightly bound to bacterial membranes and require bile salts for absorption; therefore, it is difficult to determine how significantly this source of vitamin K contributes to overall vitamin K status.
Indications
- bleeding prophylaxis
- coumarin toxicity
- familial hypocholesterolemia
- hemorrhage
- hemorrhagic disease of the newborn (HDN)
- hemorrhagic disease of the newborn (HDN) prophylaxis
- hypoprothrombinemia
- nutritional supplementation
- vitamin K deficiency
For nutritional supplementation to prevent vitamin K deficiency and/or hypoprothrombinemia
Side Effects
- anaphylactic shock
- cardiac arrest
- chest pain (unspecified)
- cyanosis
- dizziness
- dysgeusia
- dyspnea
- erythema
- flushing
- hemolysis
- hyperbilirubinemia
- hyperhidrosis
- hypotension
- injection site reaction
- jaundice
- pruritus
- rash
- respiratory arrest
- serious hypersensitivity reactions or anaphylaxis
- sinus tachycardia
- urticaria
- vesicular rash
- weakness
Monitoring Parameters
- INR
- prothrombin time (PT)
Contraindications
- anticoagulant therapy
- benzyl alcohol hypersensitivity
- biliary tract disease
- breast-feeding
- hepatic disease
- hypoprothrombinemia
- intramuscular administration
- intravenous administration
- jaundice
- neonates
- polysorbate 80 hypersensitivity
- pregnancy
- premature neonates
- serious hypersensitivity reactions or anaphylaxis
- thromboembolic disease
Interactions
- Castor Oil
- Cholestyramine
- Colesevelam
- Colestipol
- food
- Mineral Oil
- Orlistat
- Warfarin
