Phenoxybenzamine Brand Name– Dibenzyline
What is Phenoxybenzamine
Phenoxybenzamine is an antagonist at alpha-adrenergic receptors, particularly those in smooth muscle and exocrine glands. After oral administration, a “chemical sympathectomy” can be achieved.
Phenoxybenzamine is useful in the treatment of sweating and hypertension associated with pheochromocytoma; urinary symptoms of benign prostatic hypertrophy; and symptoms of certain peripheral vasospastic conditions such as acrocyanosis, Raynaud’s phenomenon, and frostbite.
The drug was approved by the FDA in 1954.
Indications
- acrocyanosis
- benign prostatic hyperplasia (BPH)
- frostbite
- pheochromocytoma
- Raynaud’s phenomenon
For the treatment of excessive sweating and hypertension associated with pheochromocytoma
Side Effects
- dizziness
- drowsiness
- ejaculation dysfunction
- fatigue
- gastritis
- miosis
- nasal congestion
- orthostatic hypotension
- sinus tachycardia
- weakness
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- breast-feeding
- cerebrovascular disease
- coronary artery disease
- dental disease
- geriatric
- heart failure
- pregnancy
- renal disease
- respiratory infection
- shock
Phenoxybenzamine is contraindicated in patients with a known hypersensitivity to the drug.
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfuzosin
- Alprostadil
- Ambrisentan
- Amifostine
- Amobarbital
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Amyl Nitrite
- Apomorphine
- Apraclonidine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Avanafil
- Baclofen
- Benzphetamine
- Beta-blockers
- Bortezomib
- Bosentan
- Brexpiprazole
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clofarabine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Enflurane
- Ephedrine
- Epinephrine
- Epoprostenol
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etomidate
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluoxetine; Olanzapine
- Fospropofol
- General anesthetics
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Intravenous Lipid Emulsions
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Ketamine
- Levodopa
- Lisdexamfetamine
- Lofexidine
- Loratadine; Pseudoephedrine
- Lovastatin; Niacin
- Lurasidone
- Mestranol; Norethindrone
- Methamphetamine
- Methohexital
- Methylphenidate
- Midodrine
- Milrinone
- Naproxen; Pseudoephedrine
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicotine
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Olanzapine
- Oxymetazoline
- Pentoxifylline
- Phendimetrazine
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Prilocaine; Epinephrine
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinidine
- Rasagiline
- Risperidone
- Ritodrine
- Segesterone Acetate; Ethinyl Estradiol
- Sevoflurane
- Sibutramine
- Sildenafil
- Silodosin
- Tadalafil
- Tamsulosin
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiopental
- Thiothixene
- Tizanidine
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Vardenafil
- Verapamil
- Yohimbine
- Ziprasidone
