Phendimetrazine

Phendimetrazine Brand Names

Bock-Arate | Bontril PDM | Bontril SR | Melfiat 105 Unicelles | Prelu-2 | Rapdone | Stabec-1

What is Phendimetrazine

Phendimetrazine is an oral, centrally-acting stimulant and sympathomimetic amine.

It is used as an adjunct to lifestyle modifications for the short-term treatment (i.e., a few weeks) of exogenous obesity. The pharmacologic effects of phendimetrazine are similar to amphetamines.

Similar to amphetamines, phendimetrazine can induce or exacerbate psychiatric symptoms (e.g., mania or psychosis), and is contraindicated in patients with a history of substance abuse due to abuse and addiction potential.

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, short-term pharmacotherapy, such as with phendimetrazine, has not been shown to produce longer-term health benefits in obese and overweight patients and cannot be generally recommended.

Phendimetrazine should not be used for long-term weight management; tolerance to the anorectic effect of stimulants has been demonstrated.

Phendimetrazine was approved by the FDA in 1961.

Indications

• obesity

For the short-term (i.e., a few weeks) treatment of exogenous obesity

Side Effects

1. abdominal pain
2. agitation
3. angina
4. blurred vision
5. cardiac valvulopathy
6. chest pain (unspecified)
7. constipation
8. depression
9. diarrhea
10. dizziness
11. dyskinesia
12. dysphoria
13. dyspnea
14. dysuria
15. EEG changes
16. euphoria
17. fatigue
18. flushing
19. headache
20. hyperhidrosis
21. hypertension
22. impotence (erectile dysfunction)
23. increased urinary frequency
24. insomnia
25. irritability
26. libido decrease
27. libido increase
28. mydriasis
29. nausea
30. ocular irritation
31. palpitations
32. peripheral edema
33. psychological dependence
34. psychosis
35. pulmonary hypertension
36. restlessness
37. sinus tachycardia
38. syncope
39. tolerance
40. tremor
41. vomiting
42. withdrawal
43. xerostomia

Monitoring Parameters

• ECG

Contraindications

• abrupt discontinuation
• alcoholism
• anorexia nervosa
• anxiety
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• children
• coronary artery disease
• depression
• diabetes mellitus
• driving or operating machinery
• geriatric
• glaucoma
• heart failure
• hypertension
• hyperthyroidism
• infants
• long QT syndrome
• mania
• MAOI therapy
• pregnancy
• psychosis
• pulmonary hypertension
• renal impairment
• stroke
• substance abuse
• suicidal ideation
• surgery
• thyroid disease
• valvular heart disease

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Ambrisentan
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amoxapine
• Arformoterol
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Azilsartan; Chlorthalidone
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Budesonide; Formoterol
• Bupropion
• Bupropion; Naltrexone
• Caffeine
• Caffeine; Ergotamine
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carteolol
• Carvedilol
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorothiazide
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Phenylephrine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Clomipramine
• Clonidine
• Cocaine
• Codeine; Phenylephrine; Promethazine
• Colchicine
• Colchicine; Probenecid
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Desipramine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Digitoxin
• Digoxin
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Dopamine
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Dronabinol
• Droxidopa
• Dulaglutide
• Dyphylline
• Dyphylline; Guaifenesin
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Hydrochlorothiazide, HCTZ
• Ephedrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esketamine
• Esmolol
• Exenatide
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Formoterol
• Formoterol; Mometasone
• Fosinopril; Hydrochlorothiazide, HCTZ
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glycopyrrolate; Formoterol
• Green Tea
• Guaifenesin; Phenylephrine
• Guanabenz
• Halothane
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Iloprost
• Imipramine
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Isocarboxazid
• Isoflurane
• Isosulfan Blue
• Labetalol
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linezolid
• Liothyronine
• Liraglutide
• Lithium
• Lixisenatide
• Lorcaserin
• Macitentan
• Maprotiline
• Mecamylamine
• Meglitinides
• Metaproterenol
• Metformin; Pioglitazone
• Metformin; Rosiglitazone
• Methyclothiazide
• Methyldopa
• Metolazone
• Metoprolol
• Midodrine
• Miglitol
• Monoamine oxidase inhibitors
• Nabilone
• Nadolol
• Nebivolol
• Nebivolol; Valsartan
• Nitrates
• Non-Ionic Contrast Media
• Norepinephrine
• Nortriptyline
• Ozanimod
• Penbutolol
• Perphenazine; Amitriptyline
• Phenelzine
• Phenoxybenzamine
• Phentermine
• Phentermine; Topiramate
• Phentolamine
• Phenylephrine
• Phenylephrine; Promethazine
• Pindolol
• Pioglitazone
• Pirbuterol
• Pramlintide
• Prazosin
• Procarbazine
• Propranolol
• Protriptyline
• Rasagiline
• Reserpine
• Riociguat
• Rosiglitazone
• Safinamide
• Salmeterol
• Selegiline
• Selexipag
• Semaglutide
• Sevoflurane
• SGLT2 Inhibitors
• Sibutramine
• Sodium Oxybate
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sulfonylureas
• Terazosin
• Terbutaline
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thyroid hormones
• Timolol
• Tranylcypromine
• Treprostinil
• Tricyclic antidepressants
• Trimipramine
• Umeclidinium; Vilanterol
• Vasodilators
• Vasopressors
• Yohimbine