Peginterferon beta 1a Brand Name– PLEGRIDY
What is Peginterferon beta 1a
Peginterferon beta 1a is available through recombinant DNA technology.
The drug is an amino acid glycoprotein that is covalently conjugated with a methoxy polyethylene glycol (PEG) molecule, which reduces clearance in vivo allowing for a more flexible dosing schedule when compared to interferon beta-1a products.
Peginterferon beta 1a is indicated for the treatment of adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Peginterferon beta 1a is administered subcutaneously every 14 days, compared to weekly or three times weekly dosage regimens with interferon beta-1a products.
Peginterferon beta-1a like other interferon beta-1a treatments, produces a significant relative reduction of annualized MS relapse rates and disability progression.
Early treatment of MS with proper therapy may delay cognitive and physical disability. The interferon beta medications are generally considered the initial treatment options for pediatric patients with MS.
Monitor closely for side effects; hepatic injury has been observed with use.
Indications
- multiple sclerosis
For the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease
Side Effects
- anaphylactoid reactions
- angioedema
- antibody formation
- arthralgia
- asthenia
- cardiomyopathy
- chills
- depression
- elevated hepatic enzymes
- fever
- headache
- heart failure
- hemolytic-uremic syndrome
- hepatic failure
- hepatitis
- hyperbilirubinemia
- hyperthermia
- hyperthyroidism
- hypothyroidism
- injection site reaction
- leukopenia
- menorrhagia
- menstrual irregularity
- myalgia
- nausea
- neutropenia
- pancytopenia
- pruritus
- psychosis
- seizures
- suicidal ideation
- thrombocytopenia
- thrombotic microangiopathy
- thrombotic thrombocytopenic purpura (TTP)
- tissue necrosis
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- platelet count
Contraindications
- alcoholism
- angina
- autoimmune disease
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- depression
- heart failure
- hemolytic-uremic syndrome
- hepatic disease
- hepatitis
- jaundice
- myocardial infarction
- pregnancy
- psychosis
- seizure disorder
- suicidal ideation
- thrombotic thrombocytopenic purpura (TTP)
- thyroid disease
Peginterferon beta-1a is contraindicated for use in patients with a history of hypersensitivity to natural or recombinant interferon beta or peginterferon.
Interactions
- Abacavir
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Amprenavir
- Atazanavir
- Atazanavir; Cobicistat
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Chloroquine
- Clozapine
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Entecavir
- Ethanol
- Fosamprenavir
- Indinavir
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lopinavir; Ritonavir
- Nelfinavir
- Nevirapine
- Ocrelizumab
- Ombitasvir; Paritaprevir; Ritonavir
- Ozanimod
- Pexidartinib
- Protease inhibitors
- Rilpivirine
- Riluzole
- Ritonavir
- Saquinavir
- Stavudine, d4T
- Telbivudine
- Tipranavir
- Vigabatrin
- Zalcitabine, ddC
- Zidovudine, ZDV
