Oxymetazoline

Oxymetazoline Brand Names

12 Hour Nasal | Afrin | Afrin Extra Moisturizing | Afrin Nasal Sinus | Afrin No Drip Severe Congestion | Dristan | Duration | Genasal | Mucinex Children’s Stuffy Nose | Mucinex Full Force | Mucinex Moisture Smart | Mucinex Sinus-Max | Mucinex Sinus-Max Sinus & Allergy | NASAL Decongestant | Nasal Relief | Neo-Synephrine 12-Hour | Neo-Synephrine Severe Sinus Congestion | Nostrilla Fast Relief | RHOFADE | Sinex 12-Hour | Sudafed OM Sinus Cold Moisturizing | Sudafed OM Sinus Congestion Moisturizing | Vicks Qlearquil Decongestant | Vicks Sinex | Vicks Sinex Severe | Vicks Sinus Daytime | Visine L.R. | Zicam Extreme Congestion Relief | Zicam Intense Sinus

What is Oxymetazoline

Oxymetazoline is an alpha adrenoreceptor agonist that acts as a topically applied sympathomimetic vasoconstrictor.

Oxymetazoline is available as a topical cream, ophthalmic solution, and an intranasal spray. The topical cream is approved to treat persistent facial erythema in adults with rosacea.

The oxymetazoline 0.1% ophthalmic solution is approved to treat adults with acquired blepharoptosis; while the 0.025% ophthalmic solution is used to relieve redness of the eye due to minor eye irritants.

The intranasal formulation is indicated to treat nasal congestion associated with acute or chronic rhinitis, sinusitis, the common cold, hay fever, and other allergies.

The maximum recommended treatment duration for the intranasal spray is 3 days; excessive or prolonged use can cause nasal mucosa irritation and recurrent nasal congestion.

This drug was approved by the FDA in 1964.

Indications

1. acne rosacea
2. blepharoptosis
3. nasal congestion
4. ocular pruritus

For the treatment of persistent facial erythema associated with acne rosacea

Side Effects

1. blurred vision
2. bradycardia
3. coma
4. conjunctival hyperemia
5. contact dermatitis
6. erythema
7. headache
8. hypertension
9. hypotension
10. hypothermia
11. keratitis
12. lethargy
13. mydriasis
14. nasal congestion
15. nasal irritation
16. nausea
17. ocular irritation
18. ocular pain
19. pruritus
20. respiratory depression
21. rhinorrhea
22. sinus tachycardia
23. sneezing
24. visual impairment
25. vomiting
26. xerophthalmia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• accidental exposure
• breast-feeding
• cardiac disease
• cerebrovascular disease
• children
• closed-angle glaucoma
• contact lenses
• coronary artery disease
• diabetes mellitus
• hypertension
• hypotension
• infants
• MAOI therapy
• neonates
• ocular exposure
• orthostatic hypotension
• pregnancy
• prostatic hypertrophy
• Raynaud’s phenomenon
• scleroderma
• Sjogren’s syndrome
• thromboangiitis obliterans (Buerger’s disease)
• thyroid disease

Interactions

• Acebutolol
• Alfuzosin
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Ambrisentan
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Atenolol
• Atenolol; Chlorthalidone
• Azilsartan
• Azilsartan; Chlorthalidone
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Beta-blockers
• Betaxolol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Brimonidine; Timolol
• Bumetanide
• Butorphanol
• Caffeine
• Calcium-channel blockers
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Cardiac glycosides
• Carteolol
• Carvedilol
• Chlorothiazide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Clevidipine
• Clonidine
• Diazoxide
• Digitoxin
• Digoxin
• Diltiazem
• Dorzolamide; Timolol
• Doxazosin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Esmolol
• Ethacrynic Acid
• Felodipine
• Fenoldopam
• Fentanyl
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Furosemide
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• Guanfacine
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Indapamide
• Irbesartan
• Isocarboxazid
• Isradipine
• Labetalol
• Levobetaxolol
• Levobunolol
• Lisinopril
• Loop diuretics
• Losartan
• Methyclothiazide
• Methyldopa
• Metolazone
• Metoprolol
• Minoxidil
• Moexipril
• Monoamine oxidase inhibitors
• Nadolol
• Nafarelin
• Nebivolol
• Nebivolol; Valsartan
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitroprusside
• Olmesartan
• Penbutolol
• Perindopril
• Perindopril; Amlodipine
• Phenelzine
• Phenoxybenzamine
• Phentolamine
• Pindolol
• Potassium-sparing diuretics
• Prazosin
• Propranolol
• Quinapril
• Ramipril
• Rasagiline
• Reserpine
• Sacubitril; Valsartan
• Selegiline
• Sotalol
• Spironolactone
• Telmisartan
• Terazosin
• Testosterone
• Thiazide diuretics
• Timolol
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Treprostinil
• Triamterene
• Valsartan
• Vasodilators
• Verapamil