Oxaprozin

Oxaprozin Brand Names- Daypro | Daypro ALTA

What is Oxaprozin

Oxaprozin is an oral nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid chemical class.

It is used for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis/juvenille idiopathic arthritis.

In adult patients with rheumatoid arthritis, the efficacy of oxaprozin 1200 mg/day orally is comparable to aspirin 3900 mg/day.

Oxaprozin is the only NSAID of the propionic acid class with a half-life long enough to support once daily administration.

All NSAIDs, including oxaprozin, cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.

The lowest effective oxaprozin dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.

Oxaprozin was FDA-approved in October 1992, and may be used in pediatric patients as young as 6 years of age for juvenille idiopathic arthritis (JIA).

While a potassium salt of oxaprozin was FDA-approved in October 2002, the product is not commercially available.

Indications

1. arthralgia
2. bone pain
3. juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
4. moderate pain
5. myalgia
6. osteoarthritis
7. rheumatoid arthritis

For the treatment of moderate pain, including arthralgia, myalgia, and bone pain†, and the management of the signs and symptoms of rheumatoid arthritis or osteoarthritis

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactic shock
5. anaphylactoid reactions
6. anemia
7. angioedema
8. anorexia
9. anxiety
10. aplastic anemia
11. aseptic meningitis
12. asthenia
13. blurred vision
14. bronchospasm
15. coma
16. confusion
17. conjunctivitis
18. constipation
19. cystitis
20. depression
21. diarrhea
22. dizziness
23. drowsiness
24. dysgeusia
25. dyspepsia
26. dysphagia
27. dyspnea
28. dysuria
29. ecchymosis
30. edema
31. elevated hepatic enzymes
32. eosinophilia
33. eructation
34. erythema multiforme
35. esophageal stricture
36. esophageal ulceration
37. esophagitis
38. exfoliative dermatitis
39. flatulence
40. gastritis
41. GI bleeding
42. GI perforation
43. glossitis
44. hallucinations
45. headache
46. hearing loss
47. heart failure
48. hematemesis
49. hematuria
50. hemolytic anemia
51. hepatic failure
52. hepatitis
53. hyperglycemia
54. hyperhidrosis
55. hypertension
56. hyponatremia
57. hypotension
58. infection
59. insomnia
60. interstitial nephritis
61. jaundice
62. leukopenia
63. maculopapular rash
64. malaise
65. melena
66. menstrual irregularity
67. myocardial infarction
68. nausea
69. nephrotic syndrome
70. odynophagia
71. oliguria
72. palpitations
73. pancreatitis
74. pancytopenia
75. paresthesias
76. peptic ulcer
77. peripheral edema
78. photosensitivity
79. platelet dysfunction
80. polyuria
81. proteinuria
82. pruritus
83. pseudoporphyria
84. purpura
85. pyrosis (heartburn)
86. rash
87. renal failure (unspecified)
88. renal papillary necrosis
89. respiratory depression
90. seizures
91. serum sickness
92. sinus tachycardia
93. sinusitis
94. Stevens-Johnson syndrome
95. stomatitis
96. stroke
97. syncope
98. thrombocytopenia
99. thromboembolism
100. tinnitus
101. toxic epidermal necrolysis
102. tremor
103. urticaria
104. vasculitis
105. vertigo
106. visual impairment
107. vomiting
108. weakness
109. weight gain
110. weight loss
111. xerostomia

Monitoring Parameters

• CBC
• LFTs
• serum creatinine/BUN
• stool guaiac

Contraindications

• acute bronchospasm
• acute myocardial infarction
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• chemotherapy
• children
• coagulopathy
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dehydration
• dental disease
• dental work
• diabetes mellitus
• edema
• geriatric
• GI bleeding
• GI disease
• GI perforation
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• hypovolemia
• immunosuppression
• infants
• infertility
• intramuscular injections
• jaundice
• labor
• myocardial infarction
• nasal polyps
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• reproductive risk
• rheumatoid arthritis
• salicylate hypersensitivity
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urticaria

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