Osimertinib Brand Name– Tagrisso
What is Osimertinib
Osimertinib is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC): either as first-line therapy in patients with exon 19 deletions or exon 21 (L858R) substitution mutations, or after progression on EGFR tyrosine kinase inhibitor (TKI) therapy in patients with T790M mutation.
The most common adverse effects are diarrhea, rash, and dry skin.
In clinical trials, serious adverse effects included pneumonia, interstitial lung disease (ILD)/pneumonitis, pulmonary embolus, and QTc prolongation
Indications
- non-small cell lung cancer (NSCLC)
For the treatment of metastatic EGFR mutation-positive non-small cell lung cancer (NSCLC)
for the first-line treatment of metastatic EGFR (exon 19 deletion or exon 21 (L858R) substitution) mutation-positive non-small cell lung cancer (NSCLC)
Side Effects
- acneiform rash
- anemia
- anemia
- anorexia
- anorexia
- asthenia
- asthenia
- back pain
- back pain
- blurred vision
- cardiomyopathy
- constipation
- constipation
- cough
- cough
- diarrhea
- diarrhea
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- erythema multiforme
- fatigue
- fatigue
- fever
- folliculitis
- headache
- headache
- heart failure
- hyperbilirubinemia
- hyperglycemia
- hypermagnesemia
- hypermagnesemia
- hypokalemia
- hypokalemia
- hyponatremia
- hyponatremia
- infection
- keratitis
- lacrimation
- lymphopenia
- lymphopenia
- maculopapular rash
- nausea
- nausea
- neutropenia
- neutropenia
- ocular pain
- onycholysis
- pneumonitis
- pneumonitis
- pruritus
- pruritus
- pulmonary edema
- pulmonary embolism
- QT prolongation
- QT prolongation
- rash
- rash
- skin erosion
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- thrombocytopenia
- thrombocytopenia
- vesicular rash
- visual impairment
- vomiting
- vomiting
- xerosis
- xerosis
Monitoring Parameters
- ECG
- ejection fraction
- pregnancy testing
- serum electrolytes
Contraindications
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiac disease
- cardiomyopathy
- celiac disease
- contraception requirements
- electrolyte imbalance
- females
- fever
- geriatric
- heart failure
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infertility
- keratitis
- long QT syndrome
- male-mediated teratogenicity
- myocardial infarction
- ocular inflammation
- pheochromocytoma
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- QT prolongation
- reproductive risk
- rheumatoid arthritis
- serious rash
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- visual impairment
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Aclidinium; Formoterol
- Afatinib
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Alpelisib
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betrixaban
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Carbamazepine
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Cobimetinib
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Crizotinib
- Cyclosporine
- Dabigatran
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Desflurane
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
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- Dolasetron
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
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- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxepin
- Doxorubicin
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- Eliglustat
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- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
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- Gemtuzumab Ozogamicin
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- Indinavir
- Inotuzumab Ozogamicin
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- Venetoclax
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- Verapamil
- Vincristine
- Vincristine Liposomal
- Voriconazole
- Vorinostat
- Ziprasidone
