Olaparib Brand Name– Lynparza
What is Olaparib
Olaparib is an oral poly (ADP-ribose) polymerase (PARP) inhibitor. PARP enzymes are involved in normal cellular homeostasis, including DNA transcription, cell cycle regulation, and DNA repair. Increased cytotoxicity and anti-tumor activity has been noted in cell lines and mouse tumor models with deficiencies in BRCA.
It is approved by the FDA for the treatment of germline or somatic BRCA-mutated (gBRCAm or sBRCAm) or suspected gBRCAm or sBRCAm advanced ovarian cancer in patients who have failed 3 or more prior courses of chemotherapy and for HER2-negative, gBRCAm metastatic breast cancer in patients previously treated with chemotherapy in the neoadjuvant, adjuvant, or metastatic setting, and metastatic castration-resistant prostate cancer in patients with a homologous recombination repair (HRR) gene mutation.
It is approved for maintenance therapy as a single agent after a response to platinum-based chemotherapy in patients with advanced BRCA-mutated ovarian cancer and in patients with gBRCAm or suspected gBRCAm metastatic pancreatic cancer.
It is also approved as first-line maintenance therapy for platinum-sensitive advanced ovarian cancer that is associated with a homologous recombination deficiency (HRD) in combination with bevacizumab.
The most common adverse reactions include anemia, nausea, fatigue, vomiting, upper respiratory infection, diarrhea, and arthralgia/myalgia.
Indications
- breast cancer
- ovarian cancer
- pancreatic cancer
- prostate cancer
For the treatment of ovarian cancer
for the first-line maintenance treatment of deleterious or suspected deleterious germline or somatic BRCA mutated (gBRCAm or sBRCAm) advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who are in a complete or partial response to first-line platinum-based chemotherapy, as monotherapy
Side Effects
- abdominal pain
- abdominal pain
- anemia
- anemia
- anorexia
- anorexia
- arthralgia
- arthralgia
- asthenia
- back pain
- colitis
- constipation
- constipation
- cough
- cystitis
- diarrhea
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- dyspnea
- edema
- erythema
- fatigue
- fatigue
- fever
- GI perforation
- headache
- headache
- hypomagnesemia
- infection
- infection
- influenza
- lethargy
- leukopenia
- leukopenia
- lymphopenia
- malaise
- musculoskeletal pain
- myalgia
- nausea
- nausea
- neutropenia
- neutropenia
- new primary malignancy
- oral ulceration
- peripheral edema
- peripheral neuropathy
- pharyngitis
- pneumonitis
- pulmonary embolism
- rash
- renal failure (unspecified)
- rhinitis
- sinusitis
- stomatitis
- stomatitis
- stroke
- thrombocytopenia
- thrombocytopenia
- thromboembolism
- vomiting
- vomiting
Monitoring Parameters
- CBC with differential
- pregnancy testing
Contraindications
- bone marrow suppression
- breast-feeding
- chemotherapy
- chronic lung disease (CLD)
- contraception requirements
- male-mediated teratogenicity
- new primary malignancy
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- radiation therapy
- reproductive risk
- thromboembolic disease
- thromboembolism
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Etravirine
- Fedratinib
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lefamulin
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Mephobarbital
- Methohexital
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Saquinavir
- Secobarbital
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Thiopental
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Verapamil
- Voriconazole
