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Nicardipine Brand Names- Cardene | Cardene IV | Cardene SR
What is Nicardipine
Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of angina and hypertension.
It is available in oral and intravenous formulations.
Nicardipine is a potent peripheral vasodilator, similar to nifedipine and other members of the dihydropyridine class. It is more selective to vascular smooth muscle than cardiac muscle and does not alter myocardial contractility or function.
When given as a continuous intravenous infusion, nicardipine can be used as a first-line agent for severe hypertension caused by a variety of etiologies.
Nicardipine is preferred when labetalol and nitroprusside are not favorable, as there is no concern for bradycardia, bronchospasm, or toxic metabolite buildup with renal impairment or prolonged use.
Indications
- angina
- diabetic nephropathy
- hypertension
- hypertensive emergency
- hypertensive urgency
- perioperative hypertension
- postoperative hypertension
- proteinuria
For the treatment of chronic stable angina
Side Effects
- angina
- anxiety
- arthralgia
- asthenia
- atrial fibrillation
- AV block
- blurred vision
- chest pain (unspecified)
- confusion
- conjunctivitis
- constipation
- depression
- diaphoresis
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- fatigue
- fever
- flushing
- gingival hyperplasia
- gynecomastia
- headache
- heart failure
- hot flashes
- hyperkinesis
- hypertonia
- hypophosphatemia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- injection site reaction
- insomnia
- malaise
- myalgia
- myocardial infarction
- nausea
- nocturia
- orthostatic hypotension
- palpitations
- paresthesias
- pericarditis
- peripheral edema
- peripheral vasodilation
- phlebitis
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- ST-T wave changes
- syncope
- thrombocytopenia
- thrombosis
- tinnitus
- tremor
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- wheezing
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- acute myocardial infarction
- angina
- aortic stenosis
- bradycardia
- breast-feeding
- cardiogenic shock
- dihydropyridine hypersensitivity
- extravasation
- gastroesophageal reflux disease (GERD)
- geriatric
- heart failure
- hepatic disease
- hiatal hernia
- hypotension
- intracranial bleeding
- neonates
- pheochromocytoma
- pregnancy
- renal failure
- renal impairment
- stroke
- ventricular dysfunction
Nicardipine is a dihydropyridine calcium-channel blocker and is contraindicated in patients with known serious dihydropyridine hypersensitivity.
Interactions
- Acalabrutinib
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alfuzosin
- Alprazolam
- Alprostadil
- Amifostine
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Atorvastatin
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzonatate
- Benzphetamine
- Betamethasone
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Brexpiprazole
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Buspirone
- Butabarbital
- Cabergoline
- Caffeine; Ergotamine
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Ciclesonide
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- Cimetidine
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- Dexmethylphenidate
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- Diazepam
- Diazoxide
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- Digoxin
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- Diphenhydramine; Naproxen
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- Dorzolamide; Timolol
- Doxorubicin
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- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enflurane
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Ergoloid Mesylates
- Ergonovine
- Ergotamine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Esomeprazole; Naproxen
- Estazolam
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- Estradiol Cypionate; Medroxyprogesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
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- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etodolac
- Etomidate
- Etonogestrel
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flibanserin
- Fluconazole
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- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- food
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- General anesthetics
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halofantrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Imatinib
- Indinavir
- Indomethacin
- Intravenous Lipid Emulsions
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ivabradine
- Ixabepilone
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lanreotide
- Lansoprazole; Naproxen
- Lasmiditan
- Lemborexant
- Levodopa
- Lisdexamfetamine
- Lithium
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lovastatin
- Lovastatin; Niacin
- Lurasidone
- Maraviroc
- Meclizine
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Melatonin
- Meloxicam
- Mephobarbital
- Mestranol; Norethindrone
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Methamphetamine
- Methohexital
- Methoxsalen
- Methylergonovine
- Methylphenidate
- Methylprednisolone
- Methysergide
- Metoprolol
- Midazolam
- Mifepristone
- Milrinone
- Mometasone
- Nabumetone
- Nadolol
- Naldemedine
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Nesiritide, BNP
- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oxaprozin
- Oxycodone
- Oxymetazoline
- Paclitaxel
- Paliperidone
- Paricalcitol
- Pasireotide
- Penbutolol
- Pentobarbital
- Pentoxifylline
- Phenelzine
- Phenobarbital
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pimozide
- Pindolol
- Piroxicam
- Posaconazole
- Prazosin
- Prednisolone
- Prednisone
- Primidone
- Procainamide
- Procaine
- Propafenone
- Propofol
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quazepam
- Quinidine
- Ranitidine
- Ranolazine
- Rasagiline
- Remifentanil
- Repaglinide
- Rifabutin
- Rifampin
- Rifapentine
- Rilpivirine
- Risperidone
- Ritonavir
- Rofecoxib
- Ruxolitinib
- Saquinavir
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selexipag
- Sevoflurane
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sincalide
- Sirolimus
- Sonidegib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Streptogramins
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- Sulindac
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- Tacrolimus
- Tamsulosin
- Telaprevir
- Telithromycin
- Temsirolimus
- Terbinafine
- Tetracaine
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- Timolol
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- Tolmetin
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- Tranylcypromine
- Trazodone
- Triamcinolone
- Triazolam
- Ubrogepant
- Ulipristal
- Valdecoxib
- Vardenafil
- Verteporfin
- Vinorelbine
- Vorapaxar
- Voriconazole
- Yohimbine
- Zafirlukast
- Ziprasidone
