Natamycin Brand Name– Natacyn
What is Natamycin
Natamycin is an ophthalmic antifungal suspension used to treat fungal blepharitis, conjunctivitis, and keratitis.
It has in vitro activity against Candida, Aspergillus, Fusarium, Acremonium (previously known as Cephalosporium), and Penicillium species.
Natamycin works by altering membrane permeability, depleting essential cellular constituents.
Because natamycin does not penetrate the cornea, conjunctiva, or other mucosal surfaces, topical application does not produce effective levels in the deep stroma or the anterior chamber.
This drug was approved by the FDA in October 1978.
Indications
- Acremonium sp.
- Aspergillus sp.
- blepharitis
- Candida sp.
- fungal conjunctivitis
- fungal keratitis
- Fusarium solani
- Fusarium sp.
- Penicillium sp.
Side Effects
- blurred vision
- chest pain (unspecified)
- corneal opacification
- dyspnea
- foreign body sensation
- hyperemia
- lacrimation
- ocular infection
- ocular irritation
- ocular pain
- paresthesias
- superinfection
Monitoring Parameters
- CBC with differential
- ophthalmologic exam
Contraindications
- breast-feeding
- children
- contact lenses
- herpes simplex keratitis (dendritic keratitis)
- infants
- intramuscular administration
- intravenous administration
- mycobacterial infection
- neonates
- pregnancy
- varicella
- viral infection
Interactions
There are no drug interactions associated with Natamycin products.
