Nadolol Brand Name– Corgard
What is Nadolol
Nadolol is an oral, nonselective, beta-adrenergic receptor antagonist similar to propranolol.
Nadolol does not demonstrate appreciable intrinsic sympathomimetic or membrane-stabilizing activities.
Unlike propranolol, nadolol is renally eliminated and possesses a low degree of lipid solubility and has the longest plasma half-life of all the beta-blockers.
The 2007 AHA guidelines for the management of hypertension state beta-blockers should not be used as first-line therapy for the treatment of hypertension, as several comparative clinical trials have shown beta blockers to be inferior to ACE inhibitors, angiotensin-receptor blockers, or calcium channel blockers for preventing both stroke and coronary artery disease complications.
These guidelines do, however, recommend the use of beta-blockers for the treatment of hypertension in patients with angina, prior myocardial infarction, or heart failure.
Nadolol was approved by the FDA in December 1989.
Indications
- angina
- anxiety
- atrial fibrillation
- atrial flutter
- esophageal varices
- hypertension
- migraine prophylaxis
- paroxysmal supraventricular tachycardia (PSVT) prophylaxis
- portal hypertension
- tremor
- variceal bleeding prophylaxis
- ventricular tachycardia prophylaxis
For the long-term management of angina pectoris
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- angioedema
- anorexia
- AV block
- bradycardia
- bronchospasm
- colitis
- constipation
- cough
- depression
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dyspnea
- elevated hepatic enzymes
- exfoliative dermatitis
- fatigue
- flatulence
- hallucinations
- headache
- heart failure
- hyperglycemia
- hypertension
- hypertriglyceridemia
- hypoglycemia
- hypotension
- impaired cognition
- impotence (erectile dysfunction)
- insomnia
- laryngospasm
- libido decrease
- nasal congestion
- nausea
- nightmares
- palpitations
- paresthesias
- peripheral vasoconstriction
- pruritus
- psychosis
- purpura
- rash
- sinus tachycardia
- skin hyperpigmentation
- syncope
- thrombosis
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- tremor
- visual impairment
- vomiting
- weight gain
- wheezing
- withdrawal
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- acute bronchospasm
- asthma
- AV block
- beta-blocker hypersensitivity
- bradycardia
- breast-feeding
- bronchitis
- cardiogenic shock
- cerebrovascular disease
- chronic obstructive pulmonary disease (COPD)
- depression
- diabetes mellitus
- dialysis
- driving or operating machinery
- emphysema
- geriatric
- heart failure
- hyperthyroidism
- hypotension
- labor
- myasthenia gravis
- obstetric delivery
- peripheral vascular disease
- pheochromocytoma
- pregnancy
- psoriasis
- pulmonary disease
- pulmonary edema
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- sick sinus syndrome
- surgery
- thyroid disease
- thyrotoxicosis
- vasospastic angina
- ventricular dysfunction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Adenosine
- Albiglutide
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amyl Nitrite
- Antithyroid agents
- Apomorphine
- Apraclonidine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Beta-agonists
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bosentan
- Bretylium
- Brexpiprazole
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Cabergoline
- Caffeine; Ergotamine
- Canagliflozin; Metformin
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Cariprazine
- Ceritinib
- Cevimeline
- Charcoal
- Chloroprocaine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Clevidipine
- Clonidine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colesevelam
- Conivaptan
- Crizotinib
- Dapagliflozin; Metformin
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desflurane
- Dexmedetomidine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazoxide
- Digoxin
- Dihydroergotamine
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Dipyridamole
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxazosin
- Dronedarone
- Dulaglutide
- Duloxetine
- Dutasteride; Tamsulosin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Encainide
- Enflurane
- Epoprostenol
- Ergonovine
- Ergotamine
- Ertugliflozin; Metformin
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Etomidate
- Exenatide
- Felodipine
- Fenoldopam
- Fingolimod
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flecainide
- Fluorescein
- Fluoxetine; Olanzapine
- Fluphenazine
- food
- Fospropofol
- Galantamine
- General anesthetics
- Ginger, Zingiber officinale
- Glipizide; Metformin
- Glucagon
- Glyburide; Metformin
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Hydralazine; Isosorbide Dinitrate, ISDN
- Icosapent ethyl
- Iloperidone
- Iloprost
- Incretin Mimetics
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Intravenous Lipid Emulsions
- Iobenguane I 131
- Isocarboxazid
- Isoflurane
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isradipine
- Itraconazole
- Ivabradine
- Ketamine
- Ketoconazole
- Lacosamide
- Lanreotide
- Lasmiditan
- Levobupivacaine
- Levodopa
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lithium
- Lixisenatide
- Lofexidine
- Lopinavir; Ritonavir
- Lovastatin; Niacin
- Lurasidone
- Magnesium Salicylate
- Mefloquine
- Meglitinides
- Meperidine; Promethazine
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methacholine
- Methohexital
- Methylergonovine
- Methysergide
- Milrinone
- Nefazodone
- Nesiritide, BNP
- Neuromuscular blockers
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oxymetazoline
- Paliperidone
- Pasireotide
- Pentoxifylline
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenothiazines
- Phenoxybenzamine
- Phentolamine
- Phenylephrine; Promethazine
- Pilocarpine
- Pramlintide
- Prazosin
- Prilocaine
- Prilocaine; Epinephrine
- Procainamide
- Procaine
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Quinidine
- Rasagiline
- Remifentanil
- Reserpine
- Risperidone
- Ritonavir
- Rivastigmine
- Ropivacaine
- Salsalate
- Semaglutide
- Sevoflurane
- SGLT2 Inhibitors
- Silodosin
- Siponimod
- Sufentanil
- Sulfonylureas
- Sympathomimetics
- Tacrine
- Tamsulosin
- Tasimelteon
- Terazosin
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiazolidinediones
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Tizanidine
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Trifluoperazine
- Verapamil
- Yohimbine
- Ziprasidone
