Mupirocin

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Mupirocin Brand Names

Bactroban | Centany | Centany AT

What is Mupirocin

Mupirocin is an antibiotic produced from Pseudomonas fluorescens that is structurally unrelated to any other topical or systemic antibiotics.

Mupirocin is used topically in the treatment of impetigo caused by Staphylococcus aureus and beta-hemolytic streptococci including Streptococcus pyogenes.

Mupirocin cream was shown to be at least as effective as oral cephalexin for the treatment of secondarily infected traumatic skin lesions.

Mupirocin is also applied intranasally to eradicate nasal colonization with methicillin-resistant strains of Staphylococcus aureus (MRSA) in adult patients and health care workers.

Intranasal application is usually done to reduce the risk of infection in patients with high risk during institutional outbreaks of MRSA.

Because of its unique mechanism, this antibiotic has little, if any, potential for cross-resistance with other antibiotics.

Mupirocin topical ointment was approved by the FDA in December 1987.

An intranasal dosage form was subsequently approved October 1995, and the topical cream was approved December 1997.

Indications

  1. bacterial colonization eradication
  2. bacterial infection prophylaxis
  3. eczema
  4. folliculitis
  5. impetigo
  6. infectious neonatal pustulosis
  7. skin and skin structure infections
  8. Staphylococcus aureus (MRSA)
  9. Staphylococcus aureus (MSSA)
  10. Staphylococcus epidermidis
  11. Streptococcus pyogenes (group A beta-hemolytic streptococci)

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. blepharitis
  5. contact dermatitis
  6. cough
  7. diarrhea
  8. dizziness
  9. dysgeusia
  10. epistaxis
  11. erythema
  12. headache
  13. infection
  14. nasal irritation
  15. nausea
  16. otalgia
  17. pharyngitis
  18. pruritus
  19. pseudomembranous colitis
  20. rash
  21. rhinitis
  22. skin irritation
  23. stomatitis
  24. superinfection
  25. urticaria
  26. xerosis
  27. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • burns
  • children
  • colitis
  • diarrhea
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • ocular exposure
  • ophthalmic administration
  • pregnancy
  • pseudomembranous colitis
  • renal impairment
  • ulcerative colitis

Interactions

There are no drug interactions associated with Mupirocin products.

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What is recurrence

What is recurrence?  Recurrence refers to an initial reduction in...

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