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Mifepristone Brand Names- Korlym | Mifeprex
What is Mifepristone
Mifepristone is a synthetic steroid with potent antiprogesterone and antiglucocorticoid activity.
It has no estrogenic, antiestrogenic, mineralocorticoid, or antimineralocorticoid activity. It is a derivative of the synthetic progestin norethindrone.
Globally, mifepristone is most widely known as a postcoital contraceptive agent and, when used in combination with a prostaglandin, as an abortifacient in early pregnancy. Off-label investigational uses for mifepristone include the treatment of leiomyomata (uterine fibroids), endometriosis, and meningiomas refractory to other therapies.
While mifepristone has also been used for cervical priming and for induction of labor at term or in the case of intrauterine fetal death, the data are insufficient to recommend its use over other available drugs.
Mifepristone has been studied for the treatment of progesterone receptor positive breast cancer but demonstrated only minimal activity as a single agent.
The initial FDA approval for mifepristone (Mifeprex) for the termination of pregnancy (in combination with misoprostol) was granted in 2000; the product is available via restricted access directly to registered prescribers in the United States, and is not available in pharmacies.
The FDA also approved mifepristone (e.g., Korlym) for chronic use in patients with endogenous Cushing’s syndrome in 2012 and the product has a limited distribution program to ensure availability to Cushing’s patients and their healthcare professionals.
Indications
- Cushing’s syndrome
- endometriosis
- meningioma
- postcoital contraception
- pregnancy termination
- uterine leiomyomata
For pregnancy termination in combination with misoprostol, through 70 days (10 weeks) gestation dated from the first day of the last menstrual period
Side Effects
- abdominal pain
- adrenocortical insufficiency
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anxiety
- arthralgia
- asthenia
- back pain
- bleeding
- chills
- constipation
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- edema
- emotional lability
- endometrial hyperplasia
- fatigue
- fetal death
- fever
- flank pain
- gastroesophageal reflux
- headache
- hot flashes
- hypertension
- hypoglycemia
- hypokalemia
- hypotension
- infection
- insomnia
- leukocytosis
- maculopapular rash
- malaise
- menstrual irregularity
- musculoskeletal pain
- myalgia
- myasthenia
- nausea
- orthostatic hypotension
- palpitations
- pelvic pain
- peripheral edema
- pharyngitis
- polydipsia
- pruritus
- rash
- sinusitis
- stomatitis
- syncope
- teratogenesis
- toxic epidermal necrolysis
- urticaria
- uterine contractions
- vaginal bleeding
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- blood glucose
- blood pressure
- pelvic exam
- pelvic ultrasound
- pregnancy testing
- urinary free cortisol
Contraindications
- abdominal pain
- adrenal insufficiency
- anticoagulant therapy
- apheresis
- AV block
- bleeding
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- coagulopathy
- contraception requirements
- contraceptive devices
- corticosteroid therapy
- diabetes mellitus
- ectopic pregnancy
- endometrial cancer
- endometrial hyperplasia
- females
- fever
- geriatric
- heart failure
- hemophilia
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hypercortisolism
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- immune thrombocytopenic purpura (ITP)
- incomplete abortion
- infection
- long QT syndrome
- myocardial infarction
- pheochromocytoma
- porphyria
- pregnancy
- pregnancy testing
- QT prolongation
- renal failure
- renal impairment
- reproductive risk
- rheumatoid arthritis
- sepsis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- vaginal bleeding
Interactions
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Ado-Trastuzumab emtansine
- Afatinib
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Antithrombin III
- Apalutamide
- Apixaban
- Apomorphine
- Aprepitant, Fosaprepitant
- Ardeparin
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Avatrombopag
- Axitinib
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bicalutamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bortezomib
- Bosentan
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Cabazitaxel
- Cabozantinib
- Caffeine; Ergotamine
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Celecoxib
- Ceritinib
- Chloramphenicol
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
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- Clomipramine
- Clonazepam
- Clozapine
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- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enflurane
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- Entrectinib
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- Eszopiclone
- Ethinyl Estradiol; Etonogestrel
- Etodolac
- Etonogestrel
- Everolimus
- Ezetimibe; Simvastatin
- Ezogabine
- Famotidine; Ibuprofen
- Fedratinib
- Felodipine
- Fenoprofen
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluvastatin
- Fluvoxamine
- Fondaparinux
- food
- Fosamprenavir
- Foscarnet
- Fosphenytoin
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- Gefitinib
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Heparin
- Histrelin
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyzine
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Indomethacin
- Inotuzumab Ozogamicin
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Lefamulin
- Lemborexant
- Lenvatinib
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levofloxacin
- Levomethadyl
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Low Molecular Weight Heparins
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Maprotiline
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Meperidine; Promethazine
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Metronidazole
- Midazolam
- Midostaurin
- Mirtazapine
- Mitotane
- Moxifloxacin
- Nabumetone
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nefazodone
- Nelfinavir
- Neratinib
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oral Contraceptives
- Oritavancin
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Oxybutynin
- Oxycodone
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- Palbociclib
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pemigatinib
- Pentamidine
- Pentosan
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
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- Pimozide
- Piroxicam
- Pitolisant
- Polatuzumab Vedotin
- Posaconazole
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
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- Protriptyline
- Quetiapine
- Quinidine
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- Red Yeast Rice
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- Repaglinide
- Retapamulin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
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- Rifapentine
- Rilpivirine
- Rimegepant
- Ripretinib
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Romidepsin
- Ruxolitinib
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulindac
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Talazoparib
- Tamoxifen
- Tamsulosin
- Tazemetostat
- Telaprevir
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thioridazine
- Thiotepa
- Thrombin Inhibitors
- Ticagrelor
- Tinzaparin
- Tipranavir
- Tofacitinib
- Tolmetin
- Tolterodine
- Tolvaptan
- Topotecan
- Toremifene
- Trabectedin
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Tucatinib
- Ubrogepant
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- Valdecoxib
- Vandetanib
- Vardenafil
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- Venetoclax
- Venlafaxine
- Verapamil
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Vorapaxar
- Voriconazole
- Vorinostat
- Voxelotor
- Warfarin
- Zaleplon
- Zanubrutinib
- Ziprasidone
- Zolpidem