Methyclothiazide

Methyclothiazide Brand Names- Aquatensen | Enduron

What is Methyclothiazide

Methyclothiazide is a thiazide diuretic and a member of the benzothiadiazine class of drugs.

It is indicated for the treatment of hypertension, and as adjunctive therapy in the management of edema associated with congestive heart failure, hepatic cirrhosis, corticosteroid therapy, or estrogen therapy.

It also has been used in patients with diabetes insipidus (off-label use).

The FDA approved methyclothiazide in 1960.

Indications

• diabetes insipidus
• edema
• hypertension

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. anorexia
6. aplastic anemia
7. azotemia
8. blurred vision
9. constipation
10. diarrhea
11. dizziness
12. dyspepsia
13. erythema multiforme
14. exfoliative dermatitis
15. fever
16. glycosuria
17. gout
18. headache
19. hemolytic anemia
20. hypercalcemia
21. hypercholesterolemia
22. hyperglycemia
23. hypertriglyceridemia
24. hyperuricemia
25. hypochloremia
26. hypokalemia
27. hypomagnesemia
28. hyponatremia
29. hypovolemia
30. impotence (erectile dysfunction)
31. interstitial nephritis
32. jaundice
33. leukopenia
34. metabolic alkalosis
35. muscle cramps
36. nausea
37. orthostatic hypotension
38. pancreatitis
39. paresthesias
40. photosensitivity
41. pneumonitis
42. polyuria
43. pulmonary edema
44. purpura
45. rash
46. restlessness
47. sialadenitis
48. Stevens-Johnson syndrome
49. thrombocytopenia
50. toxic epidermal necrolysis
51. urticaria
52. vasculitis
53. vertigo
54. vomiting
55. weakness
56. xanthopsia

Monitoring Parameters

• blood glucose
• serum calcium
• serum creatinine/BUN
• serum electrolytes
• serum magnesium
• serum uric acid

Contraindications

• acid/base imbalance
• anuria
• breast-feeding
• children
• diabetes mellitus
• electrolyte imbalance
• geriatric
• gout
• hepatic disease
• hypercalcemia
• hyperglycemia
• hyperkalemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• metabolic alkalosis
• orthostatic hypotension
• pancreatitis
• pregnancy
• renal disease
• renal failure
• renal impairment
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity

Interactions

• Acarbose
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acetohexamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alemtuzumab
• Alendronate; Cholecalciferol
• Alfentanil
• Allopurinol
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Alprostadil
• Amifostine
• Aminolevulinic Acid
• Amiodarone
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine; Dextroamphetamine Salts
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
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• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Atracurium
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• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Baclofen
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• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
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• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide; Formoterol
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• Cabergoline
• Calcium
• Calcium Phosphate, Supersaturated
• Calcium; Vitamin D
• Canagliflozin
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• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
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• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
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• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
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• Ergocalciferol, Vitamin D2
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• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Gallium Ga 68 Dotatate
• General anesthetics
• Glimepiride
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• Glimepiride; Rosiglitazone
• Glipizide
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• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Granisetron
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• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Pseudoephedrine
• Halobetasol; Tazarotene
• Halofantrine
• Haloperidol
• Halothane
• Homatropine; Hydrocodone
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen
• Ibuprofen lysine
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Icosapent ethyl
• Iloperidone
• Inamrinone
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indomethacin
• Inotersen
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• Intravenous Lipid Emulsions
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• Isoproterenol
• Isosorbide Dinitrate, ISDN
• Isosorbide Mononitrate
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• Lansoprazole; Naproxen
• Lesinurad; Allopurinol
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• Levodopa
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Loratadine; Pseudoephedrine
• Lovastatin; Niacin
• Lurasidone
• Magnesium Salts
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• Mannitol
• Meclofenamate Sodium
• Mefenamic Acid
• Meglitinides
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• Meperidine
• Meperidine; Promethazine
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• Mestranol; Norethindrone
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
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• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methotrexate
• Methoxsalen
• Methscopolamine
• Methylphenidate
• Metoclopramide
• Midodrine
• Miglitol
• Milnacipran
• Milrinone
• Mirtazapine
• Mivacurium
• Moexipril
• Morphine
• Morphine; Naltrexone
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Nefazodone
• Nesiritide, BNP
• Neuromuscular blockers
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nitrates
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• Nonsteroidal antiinflammatory drugs
• Norepinephrine
• Octreotide
• Olanzapine
• Olodaterol
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oprelvekin, rh-IL-11
• Oxaprozin
• Oxybutynin
• Oxycodone
• Oxymetazoline
• Oxymorphone
• Paliperidone
• Pancuronium
• Pantoprazole
• Paroxetine
• Pasireotide
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentoxifylline
• Perindopril
• Perindopril; Amlodipine
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• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
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• Piroxicam
• Polycarbophil
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• Porfimer
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• Propofol
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• Quetiapine
• Quinapril
• Quinidine
• Rabeprazole
• Ramipril
• Rapacuronium
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• Scopolamine
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• Sevoflurane
• Silodosin
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• Sitagliptin
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• Succinylcholine
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• Sulfacetamide
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• Tramadol
• Trandolapril
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• Trihexyphenidyl
• Trospium
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• Verteporfin
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• Vitamin D
• Vitamin D analogs
• Vorinostat
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• Ziprasidone