Meropenem and Vaborbactam Brand Name– VABOMERE
What is Meropenem and Vaborbactam
Meropenem and vaborbactam is a combination of meropenem, a carbapenem antibacterial, and vaborbactam, a beta-lactamase inhibitor, indicated for complicated urinary tract infections (cUTIs) including pyelonephritis in adults caused by susceptible E. coli, K. pneumoniae, and E. cloacae.
Meropenem and vaborbactam has activity against meropenem-resistant organisms, including Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae.
Indications
- Citrobacter freundii
- Citrobacter koseri
- Enterobacter cloacae
- Escherichia coli
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Morganella morganii
- Proteus mirabilis
- Providencia sp.
- Pseudomonas aeruginosa
- pyelonephritis
- Serratia marcescens
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactoid reactions
- angioedema
- azotemia
- bronchospasm
- candidiasis
- delirium
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- hallucinations
- headache
- hemolytic anemia
- hyperglycemia
- hyperkalemia
- hypoglycemia
- hypokalemia
- hypotension
- infection
- injection site reaction
- insomnia
- jaundice
- lethargy
- leukopenia
- nausea
- neutropenia
- paresthesias
- pharyngitis
- phlebitis
- pruritus
- pseudomembranous colitis
- rash
- seizures
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- thrombocytosis
- thrombosis
- toxic epidermal necrolysis
- tremor
- urticaria
Monitoring Parameters
- serum creatinine
Contraindications
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- colitis
- diarrhea
- driving or operating machinery
- geriatric
- GI disease
- head trauma
- inflammatory bowel disease
- neurological disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- seizure disorder
- seizures
- ulcerative colitis
Interactions
- Colchicine; Probenecid
- Oral Contraceptives
- Probenecid
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Valproic Acid, Divalproex Sodium
- Warfarin
