Lorcaserin

Lorcaserin Brand Names- Belviq | Belviq XR

What is Lorcaserin

Lorcaserin is an oral serotonin-2C (5-HT2C) receptor agonist used as an adjunct to lifestyle modifications for weight loss and chronic weight management in obese adults, or in overweight adults in the presence of at least 1 weight-related comorbidity (e.g., hypertension, dyslipidemia, type 2 diabetes).

Long-term use of lorcaserin has been associated with an average weight loss of 4% to 4.5% during clinical trials and 47.2% of patients lost 5% or more of their baseline body weight.

Favorable changes in glycemic control have been noted in addition to weight loss in those with type 2 diabetes mellitus.

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be offered as chronic treatment along with lifestyle modifications to obese patients when the potential benefits outweigh the risks.

Short-term pharmacotherapy has not been shown to produce longer-term health benefits and cannot be generally recommended.

A generalized hierarchy for medication preferences that would be applicable to all obese patients cannot currently be scientifically justified. Individualized weight loss pharmacotherapy is recommended, based upon factors such as the specific characteristics of each weight-loss medication, the presence of weight-related complications, and the medical history of the patient

Indications

• obesity
• weight management

For the treatment of obesity and for chronic weight management as an adjunct to a reduced-calorie diet and increased physical activity

Side Effects

1. anxiety
2. back pain
3. blurred vision
4. bradycardia
5. cardiac valvulopathy
6. chills
7. confusion
8. conjunctivitis
9. constipation
10. cough
11. dental pain
12. depression
13. diarrhea
14. dizziness
15. drowsiness
16. euphoria
17. fatigue
18. headache
19. hyperhidrosis
20. hyperprolactinemia
21. hypertension
22. hypoglycemia
23. impaired cognition
24. infection
25. insomnia
26. leukopenia
27. lymphopenia
28. memory impairment
29. muscle cramps
30. musculoskeletal pain
31. nausea
32. neuroleptic malignant syndrome-like symptoms
33. neutropenia
34. new primary malignancy
35. peripheral edema
36. rash
37. serotonin syndrome
38. suicidal ideation
39. tremor
40. visual impairment
41. vomiting
42. xerophthalmia
43. xerostomia

Monitoring Parameters

• blood glucose
• CBC with differential
• hemoglobin/hematocrit
• serum prolactin
• weight

Contraindications

• alcoholism
• anemia
• anorexia nervosa
• AV block
• bariatric surgery
• bradycardia
• breast-feeding
• bulimia nervosa
• bundle-branch block
• children
• contraception requirements
• depression
• diabetes mellitus
• dialysis
• driving or operating machinery
• geriatric
• heart failure
• hepatic disease
• hyperprolactinemia
• hypoglycemia
• infants
• labor
• leukemia
• leukopenia
• MAOI therapy
• multiple myeloma
• neutropenia
• new primary malignancy
• obstetric delivery
• Peyronie’s disease
• pregnancy
• priapism
• pulmonary hypertension
• renal disease
• renal failure
• renal impairment
• schizophrenia
• sick sinus syndrome
• sickle cell disease
• substance abuse
• suicidal ideation
• valvular heart disease

Lorcaserin is contraindicated in patients with prior hypersensitivity to lorcaserin or to any of the product components. Hypersensitivity reactions have been reported.

Interactions

• Acarbose
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Acetohexamide
• Albiglutide
• Alfentanil
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amphetamines
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir; Cobicistat
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Cabergoline
• Canagliflozin; Metformin
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpropamide
• Citalopram
• Clomipramine
• Cobicistat
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Degarelix
• Desipramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Doxepin
• Doxorubicin
• Dulaglutide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Ergot alkaloids
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Exenatide
• Fenfluramine
• Fentanyl
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluvoxamine
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Goserelin
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Histrelin
• Homatropine; Hydrocodone
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Imipramine
• Incretin Mimetics
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Lasmiditan
• Leuprolide
• Leuprolide; Norethindrone
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Linezolid
• Liraglutide
• Lithium
• Lixisenatide
• Loperamide
• Loperamide; Simethicone
• Meglitinides
• Meperidine
• Meperidine; Promethazine
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methylene Blue
• Miglitol
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nalbuphine
• Nateglinide
• Nebivolol
• Nebivolol; Valsartan
• Nortriptyline
• Orlistat
• Oxycodone
• Oxymorphone
• Ozanimod
• Paroxetine
• Perphenazine; Amitriptyline
• Phendimetrazine
• Phentermine
• Phentermine; Topiramate
• Phosphodiesterase inhibitors
• Pioglitazone
• Pramlintide
• Protriptyline
• Remifentanil
• Repaglinide
• Rosiglitazone
• Saxagliptin
• Selective serotonin reuptake inhibitors
• Selegiline
• Semaglutide
• Serotonin norepinephrine reuptake inhibitors
• Serotonin-Receptor Agonists
• Sertraline
• Sibutramine
• Simvastatin; Sitagliptin
• Sitagliptin
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfonylureas
• Tapentadol
• Thiazolidinediones
• Tolazamide
• Tolbutamide
• Tramadol
• Tricyclic antidepressants
• Trimipramine
• Triptorelin