Lomefloxacin Brand Name– Maxaquin
What is Lomefloxacin
Lomefloxacin is a synthetic, oral broad-spectrum fluoroquinolone antibiotic. Like other fluoroquinolones, lomefloxacin is effective against both gram-positive and gram negative bacteria.
Lomefloxacin has a longer half-life than ciprofloxacin and is administered once daily without regard to meals.
Lomefloxacin is indicated for the treatment of mild to moderate lower respiratory tract and urinary tract infections (UTIs).
Resistance has been exhibited by Streptococcous pneumoniaein vitro and therefore, lomefloxacin should not be used empirically to treat lower respiratory tract infections caused by S. pneumoniae.
Lomefloxacin was approved by the FDA in February 1992.
Indications
- Aeromonas hydrophila
- bronchitis
- Citrobacter diversus
- Citrobacter freundii
- cystitis
- Enterobacter cloacae
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Hafnia alvei
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella ozaenae
- Klebsiella pneumoniae
- Legionella pneumophila
- lower respiratory tract infections
- Moraxella catarrhalis
- Morganella morganii
- Neisseria gonorrhoeae
- Pantoea agglomerans
- Proteus mirabilis
- Proteus vulgaris
- Providencia alcalifaciens
- Providencia rettgeri
- Pseudomonas aeruginosa
- Serratia liquefaciens
- Serratia marcescens
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus saprophyticus
- surgical infection prophylaxis
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- agitation
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- asthenia
- back pain
- bradycardia
- bronchospasm
- bullous rash
- candidiasis
- cardiomyopathy
- chills
- coma
- confusion
- conjunctivitis
- constipation
- cough
- cyanosis
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- eosinophilia
- epididymitis
- epistaxis
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- flushing
- GI bleeding
- gout
- hallucinations
- headache
- heart failure
- hepatic necrosis
- hot flashes
- hyperglycemia
- hypertension
- hypertonia
- hypoglycemia
- hypotension
- increased intracranial pressure
- insomnia
- jaundice
- lacrimation
- leukorrhea
- lymphadenopathy
- maculopapular rash
- malaise
- menstrual irregularity
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- ocular pain
- otalgia
- paranoia
- paresthesias
- perineal pain
- peripheral neuropathy
- pharyngitis
- phlebitis
- photophobia
- photosensitivity
- premature ventricular contractions (PVCs)
- pruritus
- pulmonary embolism
- purpura
- QT prolongation
- rash
- respiratory depression
- restlessness
- rhinitis
- seizures
- sinus tachycardia
- skin discoloration
- skin ulcer
- stomatitis
- syncope
- tendon rupture
- thrombocytopenia
- tinnitus
- tongue discoloration
- torsade de pointes
- tremor
- urticaria
- vaginitis
- vertigo
- visual impairment
- vomiting
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- alcoholism
- atrial fibrillation
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cerebrovascular disease
- children
- colitis
- coronary artery disease
- corticosteroid therapy
- dehydration
- diabetes mellitus
- dialysis
- diarrhea
- females
- geriatric
- GI disease
- heart failure
- hepatic disease
- hepatitis
- hepatotoxicity
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infants
- inflammatory bowel disease
- jaundice
- long QT syndrome
- malnutrition
- myasthenia gravis
- myocardial infarction
- neonates
- neurotoxicity
- organ transplant
- peripheral neuropathy
- pregnancy
- pseudomembranous colitis
- QT prolongation
- quinolone hypersensitivity
- renal failure
- renal impairment
- seizure disorder
- sunlight (UV) exposure
- tendinitis
- tendinopathy
- tendon pain
- tendon rupture
- thyroid disease
- torsade de pointes
- ulcerative colitis
- viral infection
Interactions
- Acetohexamide
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Arformoterol
- Arsenic Trioxide
- Bepridil
- Budesonide; Formoterol
- Canagliflozin; Metformin
- Chloroquine
- Chlorpropamide
- Cimetidine
- Cisapride
- Clarithromycin
- Class IA Antiarrhythmics
- Clozapine
- Colchicine; Probenecid
- Cyclosporine
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Didanosine, ddI
- Dolasetron
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Flecainide
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol
- Formoterol; Mometasone
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Halofantrine
- Haloperidol
- Halothane
- Hetastarch; Dextrose; Electrolytes
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Insulins
- Isoflurane
- Levalbuterol
- Levomethadyl
- Linagliptin
- Linagliptin; Metformin
- Long-acting beta-agonists
- Magnesium
- Magnesium Salts
- Maprotiline
- Meglitinides
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Nateglinide
- Octreotide
- Olodaterol
- Pentamidine
- Phenothiazines
- Pimozide
- Pioglitazone
- Pirbuterol
- Pramlintide
- Probenecid
- Propafenone
- Ranitidine
- Repaglinide
- Risperidone
- Rosiglitazone
- Salmeterol
- Saxagliptin
- Sevoflurane
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfonylureas
- Tacrolimus
- Terbutaline
- Thiazolidinediones
- Tiotropium; Olodaterol
- Tolazamide
- Tolbutamide
- Tricyclic antidepressants
- Umeclidinium; Vilanterol
- Vardenafil
- Warfarin
- Ziprasidone
