Leuprolide Norethindrone Brand Name– Lupaneta
What is Leuprolide Norethindrone
Leuprolide acetate for depot suspension injection and norethindrone tablets are combined in a “pack” (Lupaneta Pack) for the treatment of endometriosis in adult females.
Leuprolide is a gonadotropin-releasing hormone agonist (GnRH or LH-RH agonist) and norethindrone is a synthetic oral progestin.
Efficacy for the combination was determined based on reduction in the signs and symptoms of endometriosis (dysmenorrhea, pelvic pain, deep dyspareunia, pelvic tenderness and pelvic induration).
Supression of menses was maintained in 84% of patients in the controlled clinical trials during active treatment.
The combined product was FDA approved in December 2012.
Indications
- endometriosis
For the initial management of the painful symptoms of endometriosis and for management of recurrence of symptoms
Side Effects
- acne vulgaris
- alopecia
- amenorrhea
- anaphylactoid reactions
- anxiety
- arthralgia
- asthenia
- bone fractures
- constipation
- depression
- diarrhea
- dizziness
- dyspepsia
- edema
- elevated hepatic enzymes
- emotional lability
- flatulence
- fluid retention
- headache
- hepatitis
- hepatomegaly
- hot flashes
- hyperlipidemia
- hypertension
- hypotension
- infection
- injection site reaction
- insomnia
- leukopenia
- libido decrease
- mastalgia
- memory impairment
- migraine
- muscle cramps
- muscle paralysis
- myalgia
- myocardial infarction
- nausea
- nephrolithiasis
- osteopenia
- osteoporosis
- paresthesias
- peripheral neuropathy
- photosensitivity
- pituitary apoplexy
- pulmonary embolism
- rash
- seizures
- stroke
- suicidal ideation
- synovitis
- thrombosis
- urticaria
- vaginitis
- vertigo
- vomiting
- weight gain
Monitoring Parameters
- blood pressure
- pelvic exam
Contraindications
- asthma
- breast cancer
- breast-feeding
- cardiac disease
- cervical cancer
- children
- coronary artery disease
- depression
- diabetes mellitus
- Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
- heart failure
- hepatic disease
- hyperlipidemia
- hypertension
- infants
- migraine
- neonates
- obesity
- osteoporosis
- pregnancy
- renal disease
- seizure disorder
- stroke
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thrombophlebitis
- tobacco smoking
- uterine cancer
- vaginal bleeding
- vaginal cancer
- visual disturbance
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetohexamide
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