Lanreotide Brand Name– Somatuline Depot
What is Lanreotide
Lanreotide is an analog of the naturally occurring hormone somatostatin.
Lanreotide is used to normalize growth hormone (GH) and insulin growth factor-1 (IGF-1) concentrations in patients with acromegaly who either have had an inadequate response to surgery or radiotherapy or are not candidates for such modes of treatment.
Clinical studies of lanreotide for acromegaly demonstrate that, after approximately 1 year of treatment, 51% to 86% of patients experience decreases of GH concentrations to within normal limits and 38% to 41% experience normalization of both GH and IGF-1 concentrations.
Similar to octreotide, lanreotide is also used to minimize the symptoms associated with carcinoid neuroendocrine tumors (NET) including diarrhea, abdominal pain, and flushing.
Data indicate that lanreotide exhibits antiproliferative effects on these NET tumors.
Lanreotide is also used to treat the symptoms of hyperthyroidism in patients with TSH-secreting pituitary tumors
Indications
- acromegaly
- carcinoid
- hyperthyroidism
- malignant neuroendocrine tumor (NET)
- thyrotropinoma
For the long-term treatment of acromegaly in patients who have had an inadequate response to surgery and/or radiotherapy, or for whom surgery and/or radiotherapy is not an option
NOTE: Lanreotide has been designated an orphan drug by the FDA for this indication.
Side Effects
- abdominal pain
- abdominal pain
- anaphylactoid reactions
- anemia
- angioedema
- antibody formation
- arthralgia
- back pain
- bradycardia
- cholecystitis
- cholelithiasis
- cholelithiasis
- constipation
- depression
- diabetes mellitus
- diarrhea
- dizziness
- dyspnea
- flatulence
- headache
- hematoma
- hyperglycemia
- hypertension
- hypertension
- hypertensive crisis
- hypoglycemia
- hypothyroidism
- injection site reaction
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- nausea
- pancreatitis
- pruritus
- rash
- steatorrhea
- vomiting
- vomiting
- weight loss
Monitoring Parameters
- blood glucose
- blood pressure
- gallbladder ultrasound
- heart rate
- serum growth hormone concentrations
- serum IGF-1 concentrations
- thyroid function tests (TFTs)
Contraindications
- bradycardia
- breast-feeding
- cardiac disease
- diabetes mellitus
- gallbladder disease
- hepatic disease
- hypothyroidism
- infertility
- pregnancy
- reproductive risk
- thyroid disease
Interactions
- Acarbose
- Acebutolol
- Acetohexamide
- Albiglutide
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Antidiabetic Agents
- Atenolol
- Atenolol; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Beta-adrenergic blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brimonidine; Timolol
- Bromocriptine
- Caffeine; Ergotamine
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
- Carteolol
- Carvedilol
- Chlorpropamide
- Cisapride
- Clevidipine
- Cyclosporine
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dextromethorphan; Quinidine
- Dihydroergotamine
- Diltiazem
- Dorzolamide; Timolol
- Dulaglutide
- Elexacaftor; tezacaftor; ivacaftor
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Ethosuximide
- Everolimus
- Exenatide
- Felodipine
- Fentanyl
- food
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Insulin Aspart
- Insulin Aspart; Insulin Aspart Protamine
- Insulin Degludec; Liraglutide
- Insulin Detemir
- Insulin Glargine
- Insulin Glargine; Lixisenatide
- Insulin Glulisine
- Insulin Lispro
- Insulin Lispro; Insulin Lispro Protamine
- Insulin, Inhaled
- Isophane Insulin (NPH)
- Isradipine
- Labetalol
- Lemborexant
- Lente Insulin
- Levobetaxolol
- Levobunolol
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Lutetium Lu 177 dotatate
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Metoprolol
- Miglitol
- Nadolol
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Penbutolol
- Perindopril; Amlodipine
- Pimozide
- Pindolol
- Pioglitazone
- Pramlintide
- Propranolol
- Quinidine
- Regular Insulin
- Regular Insulin; Isophane Insulin (NPH)
- Repaglinide
- Rosiglitazone
- Saxagliptin
- Semaglutide
- Simvastatin; Sitagliptin
- Sitagliptin
- Sotalol
- Tacrolimus
- Terfenadine
- Tezacaftor; Ivacaftor
- Timolol
- Tolazamide
- Tolbutamide
- Trandolapril; Verapamil
- Ultralente Insulin
- Verapamil
