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Lamivudine Tenofovir Disoproxil Fumarate Brand Names- CIMDUO | TEMIXYS
What is Lamivudine Tenofovir Disoproxil Fumarate
Lamivudine Tenofovir Disoproxil Fumarate is an oral 2-drug combination of a nucleoside reverse transcriptase inhibitor (NRTI) and an acyclic nucleoside analog (i.e., nucleotide reverse transcriptase inhibitor) approved for use with other antiretroviral medications to treat human immunodeficiency virus type 1 (HIV-1) in adult and pediatric patients weighing at least 35 kg.
This combination product allows for once-daily dosing.
Although lamivudine and tenofovir disoproxil fumarate both exhibit activity against hepatitis B virus (HBV), this drug is not indicated to treat HBV.
The FDA approved package labeling has a Black Box Warning stating that severe, acute exacerbations of hepatitis B have been reported in patients who are co-infected with HBV and HIV and have discontinued either lamivudine or tenofovir.
If treatment for HIV with lamivudine tenofovir disoproxil fumarate is discontinued in a patient coinfected with HBV, the patient should be closely monitored for several months for signs and symptoms of worsening hepatitis infection.
Due to the similarities between emtricitabine and lamivudine, lamivudine containing products are not likely to be effective in individuals who display antimicrobial resistance to emtricitabine.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
NOTE: HIV guidelines recommend consideration be given to avoiding use of tenofovir disoproxil fumarate-containing regimens in patients with renal disease and osteoporosis
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- arthralgia
- asthenia
- back pain
- bone fractures
- bone pain
- breast enlargement
- bullous rash
- Cushingoid features
- depression
- diabetes insipidus
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- Fanconi syndrome
- fever
- gynecomastia
- headache
- hematuria
- hepatitis
- hepatitis B exacerbation
- hepatomegaly
- hypercholesterolemia
- hyperglycemia
- hypertriglyceridemia
- hypokalemia
- hypophosphatemia
- infection
- insomnia
- interstitial nephritis
- lactic acidosis
- lipodystrophy
- maculopapular rash
- myalgia
- myopathy
- nausea
- neuritis
- neutropenia
- osteomalacia
- osteoporosis
- pancreatitis
- peripheral neuropathy
- polyuria
- proteinuria
- pruritus
- rash
- renal failure (unspecified)
- renal tubular necrosis
- rhabdomyolysis
- steatosis
- urticaria
- vesicular rash
- vomiting
- weakness
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum creatinine/BUN
- serum lipid profile
- serum phosphate
- serum triglycerides
- urinalysis
Contraindications
- autoimmune disease
- bone fractures
- breast-feeding
- children
- females
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatomegaly
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection resistance
- hypophosphatemia
- immune reconstitution syndrome
- obesity
- osteomalacia
- osteopenia
- osteoporosis
- pancreatitis
- peripheral neuropathy
- pregnancy
- renal disease
- renal failure
- renal impairment
- use with ribavirin
Interactions
- Acalabrutinib
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acyclovir
- Adefovir
- Alogliptin; Metformin
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bacitracin
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bepridil
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bortezomib
- Brigatinib
- Cabozantinib
- Canagliflozin; Metformin
- Capmatinib
- Carboplatin
- Carvedilol
- Celecoxib
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisplatin
- Clarithromycin
- Clofarabine
- Colchicine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Conivaptan
- Cyclosporine
- Dapagliflozin; Metformin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dextromethorphan; Quinidine
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Donepezil; Memantine
- Dronedarone
- Echinacea
- Efavirenz; Emtricitabine; Tenofovir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole; Naproxen
- Etodolac
- Etravirine
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- food
- Foscarnet
- Fostamatinib
- Ganciclovir
- Gentamicin
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Hydrocodone; Ibuprofen
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Interferon Alfa-2b; Ribavirin
- Interferons
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Isosulfan Blue
- Istradefylline
- Itraconazole
- Ivacaftor
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Ledipasvir; Sofosbuvir
- Linagliptin; Metformin
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Magnesium Salicylate
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Memantine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Mifepristone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nelfinavir
- Neratinib
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Ombitasvir; Paritaprevir; Ritonavir
- Orlistat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Pamidronate
- Paromomycin
- Piroxicam
- Plazomicin
- Polymyxin B
- Polymyxins
- Posaconazole
- Probenecid
- Procainamide
- Propafenone
- Quinidine
- Ranolazine
- Regorafenib
- Ribavirin
- Rifaximin
- Ritonavir
- Rofecoxib
- Rolapitant
- Salicylates
- Salsalate
- Sapropterin
- Saquinavir
- Simeprevir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sorafenib
- Sorbitol
- Streptomycin
- Sulindac
- Tacrolimus
- Tafamidis
- Tedizolid
- Telaprevir
- Telithromycin
- Temsirolimus
- Testosterone
- Tezacaftor; Ivacaftor
- Ticagrelor
- Tipranavir
- Tobramycin
- Tolmetin
- Tolvaptan
- Trandolapril; Verapamil
- Trospium
- Tucatinib
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Vancomycin
- Vemurafenib
- Verapamil
- Zoledronic Acid
- Zonisamide
