Ketoprofen

Ketoprofen Brand Names

Active-Ketoprofen 5% | Actron | Orudis | Oruvail

What is Ketoprofen

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid chemical class.

Ketoprofen possesses analgesic and antipyretic properties. As a propionic acid derivative, ketoprofen is chemically and pharmacologically related to ibuprofen. Immediate-release formulations are useful for the treatment of acute pain.

Ketoprofen 25—100 mg exerted similar analgesic effects for postoperative pain as acetaminophen 650 mg and codeine 60 mg or acetaminophen 650 mg and oxycodone 10 mg.

Clinical studies have demonstrated its effectiveness in treating ankylosing spondylitis and acute gouty arthritis.

All NSAIDs including ketoprofen cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.

The lowest effective ketoprofen dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use. Ketoprofen was approved by the FDA in January 1986.

In October 1995, a 12.5 mg OTC tablet was FDA approved for marketing. The FDA approved a 12.5 mg oral soluble film for the temporary relief of minor aches and pains in November 2009; product launch information is pending.

Indications

1. ankylosing spondylitis
2. arthralgia
3. bone pain
4. dental pain
5. dysmenorrhea
6. fever
7. gouty arthritis
8. headache
9. migraine prophylaxis
10. mild pain
11. moderate pain
12. myalgia
13. osteoarthritis
14. rheumatoid arthritis

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. amnesia
5. anaphylactoid reactions
6. anemia
7. angioedema
8. anorexia
9. appetite stimulation
10. arrhythmia exacerbation
11. aseptic meningitis
12. azotemia
13. bronchospasm
14. bullous rash
15. chills
16. cholestasis
17. confusion
18. conjunctivitis
19. constipation
20. cystitis
21. depression
22. diabetes mellitus
23. diaphoresis
24. diarrhea
25. dizziness
26. drowsiness
27. dysgeusia
28. dyspepsia
29. dysphagia
30. dysphoria
31. dyspnea
32. dysuria
33. elevated hepatic enzymes
34. epistaxis
35. eructation
36. erythema multiforme
37. esophageal stricture
38. esophageal ulceration
39. esophagitis
40. exfoliative dermatitis
41. flatulence
42. gastritis
43. GI bleeding
44. GI perforation
45. gynecomastia
46. hallucinations
47. headache
48. hearing loss
49. heart failure
50. hematemesis
51. hematuria
52. hemolysis
53. hepatic failure
54. hepatic necrosis
55. hepatitis
56. hyperkalemia
57. hypersalivation
58. hypertension
59. hyperuricemia
60. hyponatremia
61. impotence (erectile dysfunction)
62. infection
63. insomnia
64. interstitial nephritis
65. jaundice
66. laryngeal edema
67. libido decrease
68. libido increase
69. malaise
70. melena
71. migraine
72. myalgia
73. myocardial infarction
74. nausea
75. nephrotic syndrome
76. nightmares
77. nocturia
78. ocular pain
79. odynophagia
80. oliguria
81. onycholysis
82. palpitations
83. pancreatitis
84. paresthesias
85. peptic ulcer
86. peripheral edema
87. peripheral vasodilation
88. pharyngitis
89. photosensitivity
90. platelet dysfunction
91. polyuria
92. proteinuria
93. pruritus
94. purpura
95. pyrosis (heartburn)
96. rash
97. renal failure (unspecified)
98. renal papillary necrosis
99. retinal hemorrhage
100. retinal pigment changes
101. rhinitis
102. sinus tachycardia
103. skin discoloration
104. steatosis
105. Stevens-Johnson syndrome
106. stomatitis
107. stroke
108. thrombocytopenia
109. thromboembolism
110. tinnitus
111. toxic epidermal necrolysis
112. urticaria
113. vertigo
114. visual impairment
115. vomiting
116. weight gain
117. weight loss
118. xerostomia

Monitoring Parameters

• CBC
• LFTs
• serum creatinine/BUN
• stool guaiac

Contraindications

• acute bronchospasm
• acute myocardial infarction
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• chemotherapy
• coagulopathy
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dehydration
• dental disease
• dental work
• diabetes mellitus
• edema
• geriatric
• GI bleeding
• GI disease
• GI perforation
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• hypoalbuminemia
• hypovolemia
• immunosuppression
• intramuscular injections
• jaundice
• labor
• lactase deficiency
• myocardial infarction
• nasal polyps
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• rheumatoid arthritis
• salicylate hypersensitivity
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urticaria

Interactions

• Abciximab
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
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• Acetohexamide
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