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Isosorbide Mononitrate Brand Names
Imdur | Ismo | Isotrate ER | Monoket
What is Isosorbide Mononitrate
Isosorbide Mononitrate the long-acting metabolite of isosorbide dinitrate, is a vasodilatory agent used for the prophylactic management of angina pectoris.
Isosorbide mononitrate is not subject to first-pass metabolism and therefore has improved bioavailability and a significantly longer half-life than isosorbide dinitrate.
Isosorbide mononitrate (Ismo™) was approved by the FDA in December 1991. Monoket®, a second immediate-release isosorbide mononitrate product, was granted FDA approval in June 1993.
An extended-release formulation (Imdur®) was approved by the FDA in August 1993.
Indications
- angina
- esophageal varices
- portal hypertension
- variceal bleeding prophylaxis
For the chronic treatment of angina pectoris due to coronary artery disease
Side Effects
- abdominal pain
- acne vulgaris
- amblyopia
- anemia
- angina
- anorexia
- anxiety
- arrhythmia exacerbation
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- bradycardia
- bronchospasm
- bundle-branch block
- candidiasis
- chest pain (unspecified)
- confusion
- conjunctivitis
- constipation
- cough
- cyanosis
- depression
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- emotional lability
- fatigue
- flatulence
- flushing
- gastritis
- glossitis
- headache
- heart failure
- hemorrhoids
- hot flashes
- hyperhidrosis
- hypertension
- hyperuricemia
- hypoesthesia
- hypokalemia
- hypotension
- impotence (erectile dysfunction)
- infection
- insomnia
- libido decrease
- malaise
- melena
- methemoglobinemia
- migraine
- muscle cramps
- musculoskeletal pain
- myalgia
- myocardial infarction
- nasal congestion
- nausea
- neuritis
- nightmares
- orthostatic hypotension
- pallor
- palpitations
- paresis
- paresthesias
- pharyngitis
- photophobia
- polyuria
- pruritus
- ptosis
- purpura
- rash
- restlessness
- rhinitis
- sinus tachycardia
- sinusitis
- syncope
- thrombocytopenia
- tinnitus
- tolerance
- torticollis
- tremor
- vaginitis
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weakness
- weight loss
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- anemia
- breast-feeding
- cardiomyopathy
- children
- closed-angle glaucoma
- dehydration
- geriatric
- head trauma
- hepatic disease
- hypotension
- hypovolemia
- increased intracranial pressure
- infants
- intracranial bleeding
- myocardial infarction
- neonates
- nitrate hypersensitivity
- orthostatic hypotension
- pregnancy
- syncope
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acrivastine; Pseudoephedrine
- Alfuzosin
- Alpha-blockers
- Amphetamine
- Amphetamine; Dextroamphetamine
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apomorphine
- Articaine; Epinephrine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Benzphetamine
- Beta-adrenergic blockers
- Bosentan
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Cabergoline
- Caffeine; Ergotamine
- Calcium-channel blockers
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carbonic anhydrase inhibitors
- Central-acting adrenergic agents
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Dapsone
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diazoxide
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Ephedrine
- Epinephrine
- Eplerenone
- Epoprostenol
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Fenoldopam
- Fexofenadine; Pseudoephedrine
- Gallium Ga 68 Dotatate
- Glimepiride; Rosiglitazone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halothane
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Iloprost
- Isoproterenol
- Lidocaine
- Lidocaine; Prilocaine
- Lisdexamfetamine
- Loop diuretics
- Loratadine; Pseudoephedrine
- Mannitol
- Mecamylamine
- Mepenzolate
- Mepivacaine
- Mepivacaine; Levonordefrin
- Metformin; Rosiglitazone
- Methamphetamine
- Methazolamide
- Methylergonovine
- Methylphenidate
- Methysergide
- Midodrine
- Minoxidil
- Naproxen; Pseudoephedrine
- Nesiritide, BNP
- Nitroprusside
- Norepinephrine
- Paliperidone
- Pemoline
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pergolide
- Phendimetrazine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phosphodiesterase inhibitors
- Potassium-sparing diuretics
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Pseudoephedrine
- Racepinephrine
- Reserpine
- Riociguat
- Ritodrine
- Ropivacaine
- Rosiglitazone
- Sincalide
- Sympathomimetics
- Tetracaine
- Thiazide diuretics
- Treprostinil
